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Adjuvant treatment of recalcitrant Bullous pemphigoid with immunoadsorption
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-196620
- Elimination of pathogenic autoantibodies by immunoadsorption (IA) has been described as an effective adjuvant treatment in severe bullous autoimmune diseases, especially in pemphigus. There is much less experience in the treatment of bullous pemphigoid (BP). BP was diagnosed in a 62-year-old Caucasian woman presenting a pruritic rash with multiple tense blisters. Standard treatments with topical and oral corticosteroids, steroid-sparing agents including dapsone, azathioprine, mycophenolate mofetil (MMF) and intravenous immunoglobulins wereElimination of pathogenic autoantibodies by immunoadsorption (IA) has been described as an effective adjuvant treatment in severe bullous autoimmune diseases, especially in pemphigus. There is much less experience in the treatment of bullous pemphigoid (BP). BP was diagnosed in a 62-year-old Caucasian woman presenting a pruritic rash with multiple tense blisters. Standard treatments with topical and oral corticosteroids, steroid-sparing agents including dapsone, azathioprine, mycophenolate mofetil (MMF) and intravenous immunoglobulins were ineffective or had to be discontinued due to adverse events. An immediate clinical response could be achieved by two treatment cycles of adjuvant protein A immunoadsorption (PA-IA) in addition to continued treatment with MMF (2 g/day) and prednisolone (1 mg/kg/day). Tolerance was excellent. Clinical improvement remained stable after discontinuation of IA and went along with sustained reduction of circulating autoantibodies. Our data demonstrate that PA-IA might be a safe and effective adjuvant treatment in severe and recalcitrant BP.…
Autor(en): | P.A. Müller, E.B. Bröcker, E. Klinker, J. Stoevesandt, S. Benoit |
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URN: | urn:nbn:de:bvb:20-opus-196620 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie |
Medizinische Fakultät / Institut für Klinische Transfusionsmedizin und Hämotherapie | |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Dermatology |
ISSN: | 1018-8665 |
ISSN: | 1421-9832 |
Erscheinungsjahr: | 2012 |
Band / Jahrgang: | 224 |
Heft / Ausgabe: | 3 |
Erste Seite: | 224 |
Letzte Seite: | 227 |
Originalveröffentlichung / Quelle: | Dermatology (2012) 224:3, 224-227. https://doi.org/10.1159/000339071 |
DOI: | https://doi.org/10.1159/000339071 |
PubMed-ID: | https://pubmed.ncbi.nlm.nih.gov/22678083 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | Bullous pemphigoid; Immunoadsorption; Immunoapheresis |
Datum der Freischaltung: | 23.03.2022 |
Datum der Erstveröffentlichung: | 05.06.2012 |
Anmerkungen: | This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively. |
Lizenz (Deutsch): | Deutsches Urheberrecht |