- Treffer 1 von 1
Candida lusitaniae breakthrough fungemia in an immuno-compromised adolescent: case report and review of the literature
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-220125
- Candida lusitaniae is a rare cause of candidemia that is known for its unique capability to rapidly acquire resistance to amphotericin B. We report the case of an adolescent with grade IV graft-vs.-host disease after hematopoietic cell transplantation who developed catheter-associated C. lusitaniae candidemia while on therapeutic doses of liposomal amphotericin B. We review the epidemiology of C. lusitaniae bloodstream infections in adult and pediatric patients, the development of resistance, and its role in breakthrough candidemia. AppropriateCandida lusitaniae is a rare cause of candidemia that is known for its unique capability to rapidly acquire resistance to amphotericin B. We report the case of an adolescent with grade IV graft-vs.-host disease after hematopoietic cell transplantation who developed catheter-associated C. lusitaniae candidemia while on therapeutic doses of liposomal amphotericin B. We review the epidemiology of C. lusitaniae bloodstream infections in adult and pediatric patients, the development of resistance, and its role in breakthrough candidemia. Appropriate species identification, in vitro susceptibility testing, and source control are pivotal to optimal management of C. lusitaniae candidemia. Initial antifungal therapy may consist of an echinocandin and be guided by in vitro susceptibility and clinical response.…
Autor(en): | Athanasia Apsemidou, Miriam Antonie Füller, Evgeny A. Idelevich, Oliver Kurzai, Athanasios Tragiannidis, Andreas H. Groll |
---|---|
URN: | urn:nbn:de:bvb:20-opus-220125 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Institut für Hygiene und Mikrobiologie |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Journal of Fungi |
ISSN: | 2309-608X |
Erscheinungsjahr: | 2020 |
Band / Jahrgang: | 6 |
Heft / Ausgabe: | 4 |
Aufsatznummer: | 380 |
Originalveröffentlichung / Quelle: | Journal of Fungi (2020) 6:4, 380. https://doi.org/10.3390/jof6040380 |
DOI: | https://doi.org/10.3390/jof6040380 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | Candida lusitaniae; breakthrough; candidemia; infection; resistance; transplantation |
Datum der Freischaltung: | 02.08.2022 |
Datum der Erstveröffentlichung: | 21.12.2020 |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |