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Disruption of the CNTF gene results in motor neuron degeneration
Please always quote using this URN: urn:nbn:de:bvb:20-opus-33038
- CNTF is a cytosolic molecule expressed postnatally in myelinating Schwann cells and in a subpopulation of astrocytes. Although CNTF administration prevents lesion-mediated and genetically determined motor neuron degeneration, its physiological function remained elusive. Here it is reported that abolition of CNTF gene expression by homologous recombination results in a progressive atrophy and loss of motor neurons in adult mice, which is functionally reflected by a small but significant reduction in muscle strength.
Author: | Yasuo Masu, Eckhard Wolf, Bettina Holtmann, Michael Sendtner, Gottfried Brem, Hans Thoenen |
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URN: | urn:nbn:de:bvb:20-opus-33038 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Institut für Klinische Neurobiologie |
Language: | English |
Year of Completion: | 1993 |
Source: | In: Nature (1993) 365, 27-32. |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Release Date: | 2009/08/25 |