Trabeculopuncture as a predictive test of distal outflow resistance in canal-based surgery
Please always quote using this URN: urn:nbn:de:bvb:20-opus-299740
- We investigated whether trabeculopuncture (TP) could detect distal outflow resistance to predict the outcome of canal-based glaucoma surgery such as ab interno trabeculectomy (AIT). These procedures have a high utilization in open angle glaucoma, but fail in eyes with an unidentified distal outflow resistance. We assigned 81 porcine eyes to two groups: trial (n = 42) and control (n = 39). At 24 h, four YAG-laser trabeculopunctures were placed nasally, followed by a 180° AIT at the same site at 48 h. The proportion of TP responders between bothWe investigated whether trabeculopuncture (TP) could detect distal outflow resistance to predict the outcome of canal-based glaucoma surgery such as ab interno trabeculectomy (AIT). These procedures have a high utilization in open angle glaucoma, but fail in eyes with an unidentified distal outflow resistance. We assigned 81 porcine eyes to two groups: trial (n = 42) and control (n = 39). At 24 h, four YAG-laser trabeculopunctures were placed nasally, followed by a 180° AIT at the same site at 48 h. The proportion of TP responders between both AIT groups was compared. Histology and outflow canalograms were determined. Both post-TP and post-AIT IOPs were lower than baseline IOP (p = 0.015 and p < 0.01, respectively). The success rates of TP and AIT were 69% and 85.7%, respectively. Sensitivity and specificity values of TP as predictive test for AIT success were 77.7% and 83.3%, respectively. The positive and negative predictive values were 96.6% and 38.5%, respectively. We conclude that a 10% reduction in IOP after TP can be used as a predictor for the success (> 20% IOP decrease) of 180° AIT in porcine eyes.…
Author: | R. Verma-Fuehring, M. Dakroub, H. Han, J. Hillenkamp, N. A. Loewen |
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URN: | urn:nbn:de:bvb:20-opus-299740 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Augenklinik und Poliklinik |
Language: | English |
Parent Title (English): | Scientific Reports |
Year of Completion: | 2022 |
Volume: | 12 |
Article Number: | 10584 |
Source: | Scientific Reports (2022) 12:10584. https://doi.org/10.1038/s41598-022-13990-9 |
DOI: | https://doi.org/10.1038/s41598-022-13990-9 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | eye diseases; glaucoma |
Release Date: | 2023/05/03 |
Open-Access-Publikationsfonds / Förderzeitraum 2022 | |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |