An update on the LIM and SH3 domain protein 1 (LASP1): a versatile structural, signaling, and biomarker protein
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-144546
- The gene encoding the LIM and SH3 domain protein (LASP1) was cloned two decades ago from a cDNA library of breast cancer metastases. As the first protein of a class comprising one N-terminal LIM and one C-terminal SH3 domain, LASP1 founded a new LIM-protein subfamily of the nebulin group. Since its discovery LASP1 proved to be an extremely versatile protein because of its exceptional structure allowing interaction with various binding partners, its ubiquitous expression in normal tissues, albeit with distinct expression patterns, and itsThe gene encoding the LIM and SH3 domain protein (LASP1) was cloned two decades ago from a cDNA library of breast cancer metastases. As the first protein of a class comprising one N-terminal LIM and one C-terminal SH3 domain, LASP1 founded a new LIM-protein subfamily of the nebulin group. Since its discovery LASP1 proved to be an extremely versatile protein because of its exceptional structure allowing interaction with various binding partners, its ubiquitous expression in normal tissues, albeit with distinct expression patterns, and its ability to transmit signals from the cytoplasm into the nucleus. As a result, LASP1 plays key roles in cell structure, physiological processes, and cell signaling. Furthermore, LASP1 overexpression contributes to cancer aggressiveness hinting to a potential value of LASP1 as a cancer biomarker. In this review we summarize published data on structure, regulation, function, and expression pattern of LASP1, with a focus on its role in human cancer and as a biomarker protein. In addition, we provide a comprehensive transcriptome analysis of published microarrays (n=2,780) that illustrates the expression profile of LASP1 in normal tissues and its overexpression in a broad range of human cancer entities.…
Autor(en): | Martin F. Orth, Alex Cazes, Elke Butt, Thomas G. P. Grunewald |
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URN: | urn:nbn:de:bvb:20-opus-144546 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Institut für Klinische Biochemie und Pathobiochemie |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Oncotarget |
Erscheinungsjahr: | 2015 |
Band / Jahrgang: | 6 |
Heft / Ausgabe: | 1 |
Seitenangabe: | 26-42 |
Originalveröffentlichung / Quelle: | Oncotarget 2015, Vol. 6, No. 1, 26-42. DOI: 10.18632/oncotarget.3083 |
DOI: | https://doi.org/10.18632/oncotarget.3083 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | LASP1; biomarker; cancer; microRNA; nucleo-cytoplasmic |
Datum der Freischaltung: | 28.01.2019 |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung |