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The influence of capsaicin on the integrity of microvascular endothelial cell monolayers
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-284865
- Microvascular endothelial cells are an essential part of many biological barriers, such as the blood–brain barrier (BBB) and the endothelium of the arteries and veins. A reversible opening strategy to increase the permeability of drugs across the BBB could lead to improved therapies due to enhanced drug bioavailability. Vanilloids, such as capsaicin, are known to reversibly open tight junctions of epithelial and endothelial cells. In this study, we used several in vitro assays with the murine endothelial capillary brain cells (line cEND) as aMicrovascular endothelial cells are an essential part of many biological barriers, such as the blood–brain barrier (BBB) and the endothelium of the arteries and veins. A reversible opening strategy to increase the permeability of drugs across the BBB could lead to improved therapies due to enhanced drug bioavailability. Vanilloids, such as capsaicin, are known to reversibly open tight junctions of epithelial and endothelial cells. In this study, we used several in vitro assays with the murine endothelial capillary brain cells (line cEND) as a BBB model to characterize the interaction between capsaicin and endothelial tight junctions.…
Autor(en): | Mathias Kaiser, Malgorzata Burek, Stefan Britz, Frauke Lankamp, Steffi Ketelhut, Björn Kemper, Carola Förster, Christian Gorzelanny, Francisco M. Goycoolea |
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URN: | urn:nbn:de:bvb:20-opus-284865 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Klinik und Poliklinik für Anästhesiologie (ab 2004) |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | International Journal of Molecular Sciences |
ISSN: | 1422-0067 |
Erscheinungsjahr: | 2018 |
Band / Jahrgang: | 20 |
Heft / Ausgabe: | 1 |
Aufsatznummer: | 122 |
Originalveröffentlichung / Quelle: | International Journal of Molecular Sciences (2019) 20:1, 122. https://doi.org/10.3390/ijms20010122 |
DOI: | https://doi.org/10.3390/ijms20010122 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | capsaicin; endothelial cells; tight junctions |
Datum der Freischaltung: | 05.06.2023 |
Datum der Erstveröffentlichung: | 30.12.2018 |
EU-Projektnummer / Contract (GA) number: | 613931 |
OpenAIRE: | OpenAIRE |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |