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Novel functional renal PET imaging with 18F-FDS in human subjects
Please always quote using this URN: urn:nbn:de:bvb:20-opus-174634
- The novel PET probe 2-deoxy-2-18F-fluoro-D-sorbitol (18F-FDS) has demonstrated favorable renal kinetics in animals. We aimed to elucidate its imaging properties in two human volunteers. 18F-FDS was produced by a simple one-step reduction from 18F-FDG. On dynamic renal PET, the cortex was delineated and activity gradually transited in the parenchyma, followed by radiotracer excretion. No adverse effects were reported. Given the higher spatiotemporal resolution of PET relative to conventional scintigraphy, 18F-FDS PET offers a more thoroughThe novel PET probe 2-deoxy-2-18F-fluoro-D-sorbitol (18F-FDS) has demonstrated favorable renal kinetics in animals. We aimed to elucidate its imaging properties in two human volunteers. 18F-FDS was produced by a simple one-step reduction from 18F-FDG. On dynamic renal PET, the cortex was delineated and activity gradually transited in the parenchyma, followed by radiotracer excretion. No adverse effects were reported. Given the higher spatiotemporal resolution of PET relative to conventional scintigraphy, 18F-FDS PET offers a more thorough evaluation of human renal kinetics. Due to its simple production from 18F-FDG, 18F-FDS is virtually available at any PET facility with radiochemistry infrastructure.…
Author: | Rudolf A. Werner, Alvaro A. Ordonez, Julian Sanchez-Bautista, Charles Marcus, Constantin Lapa, Steven P. Rowe, Martin G. Pomper, Jeffrey P. Leal, Martin A. Lodge, Mehrbod S. Javadi, Sanjay K. Jain, Takahiro Higuchi |
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URN: | urn:nbn:de:bvb:20-opus-174634 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Klinik und Poliklinik für Nuklearmedizin |
Language: | English |
Parent Title (English): | Clinical Nuclear Medicine |
ISSN: | 0363-9762 |
Year of Completion: | 2019 |
Volume: | 44 |
Issue: | 5 |
Pagenumber: | 410-411 |
Source: | Clinical Nuclear Medicine (2019) 44, 5, p. 410-411. doi: 10.1097/RLU.0000000000002494 |
Sonstige beteiligte Institutionen: | Johns Hopkins School of Medicine |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
GND Keyword: | Positronen-Emissions-Tomografie |
Tag: | 18F-FDS; 2-deoxy-2-18F-fluoro-D-sorbitol; Positron-Emission Tomography; kidney; renal imaging; split renal function |
Release Date: | 2019/06/04 |
EU-Project number / Contract (GA) number: | 701983 |
OpenAIRE: | OpenAIRE |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |