Cancer research using organoid technology
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-235377
- Organoid technology has rapidly transformed basic biomedical research and contributed to significant discoveries in the last decade. With the application of protocols to generate organoids from cancer tissue, organoid technology has opened up new opportunities for cancer research and therapy. Using organoid cultures derived from healthy tissues, different aspects of tumour initiation and progression are widely studied including the role of pathogens or specific cancer genes. Cancer organoid cultures, on the other hand, are applied to generateOrganoid technology has rapidly transformed basic biomedical research and contributed to significant discoveries in the last decade. With the application of protocols to generate organoids from cancer tissue, organoid technology has opened up new opportunities for cancer research and therapy. Using organoid cultures derived from healthy tissues, different aspects of tumour initiation and progression are widely studied including the role of pathogens or specific cancer genes. Cancer organoid cultures, on the other hand, are applied to generate biobanks, perform drug screens, and study mutational signatures. With the incorporation of cellular components of the tumour microenvironment such as immune cells into the organoid cultures, the technology is now also exploited in the rapidly advancing field of immuno-oncology. In this review, I discuss how organoid technology is currently being utilised in cancer research and what obstacles are still to be overcome for its broader use in anti-cancer therapy.…
Autor(en): | Kai KretzschmarORCiD |
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URN: | urn:nbn:de:bvb:20-opus-235377 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Medizinische Klinik und Poliklinik II |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Journal of Molecular Medicine |
ISSN: | 0946-2716 |
Erscheinungsjahr: | 2020 |
Band / Jahrgang: | 99 |
Seitenangabe: | 501–515 |
Originalveröffentlichung / Quelle: | Journal of Molecular Medicine (2021) 99:501–515. https://doi.org/10.1007/s00109-020-01990-z |
DOI: | https://doi.org/10.1007/s00109-020-01990-z |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | 3D culture; cancer; drug screening; immuno-oncology; organoids; personalised medicine; pre-clinical models |
Datum der Freischaltung: | 23.06.2021 |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |