Extracellular matrix metalloproteinase inducer EMMPRIN (CD147) in cardiovascular disease
Please always quote using this URN: urn:nbn:de:bvb:20-opus-285014
- The receptor EMMPRIN is involved in the development and progression of cardiovascular diseases and in the pathogenesis of myocardial infarction. There are several binding partners of EMMPRIN mediating the effects of EMMPRIN in cardiovascular diseases. EMMPRIN interaction with most binding partners leads to disease progression by mediating cytokine or chemokine release, the activation of platelets and monocytes, as well as the formation of monocyte-platelet aggregates (MPAs). EMMPRIN is also involved in atherosclerosis by mediating theThe receptor EMMPRIN is involved in the development and progression of cardiovascular diseases and in the pathogenesis of myocardial infarction. There are several binding partners of EMMPRIN mediating the effects of EMMPRIN in cardiovascular diseases. EMMPRIN interaction with most binding partners leads to disease progression by mediating cytokine or chemokine release, the activation of platelets and monocytes, as well as the formation of monocyte-platelet aggregates (MPAs). EMMPRIN is also involved in atherosclerosis by mediating the infiltration of pro-inflammatory cells. There is also evidence that EMMPRIN controls energy metabolism of cells and that EMMPRIN binding partners modulate intracellular glycosylation and trafficking of EMMPRIN towards the cell membrane. In this review, we systematically discuss these multifaceted roles of EMMPRIN and its interaction partners, such as Cyclophilins, in cardiovascular disease.…
Author: | Saskia N. I. von Ungern-Sternberg, Alma Zernecke, Peter Seizer |
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URN: | urn:nbn:de:bvb:20-opus-285014 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Institut für Experimentelle Biomedizin |
Language: | English |
Parent Title (English): | International Journal of Molecular Sciences |
ISSN: | 1422-0067 |
Year of Completion: | 2018 |
Volume: | 19 |
Issue: | 2 |
Article Number: | 507 |
Source: | International Journal of Molecular Sciences (2018) 19:2, 507. https://doi.org/10.3390/ijms19020507 |
DOI: | https://doi.org/10.3390/ijms19020507 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | cardiovascular disease; immunoglobulin superfamily; inflammation; monocyte-platelet aggregates; platelets |
Release Date: | 2023/05/31 |
Date of first Publication: | 2018/02/08 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |