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Deletion of Batf3-dependent antigen-presenting cells does not affect atherosclerotic lesion formation in mice

Please always quote using this URN: urn:nbn:de:bvb:20-opus-170535
  • Atherosclerosis is the main underlying cause for cardiovascular events such as myocardial infarction and stroke and its development might be influenced by immune cells. Dendritic cells (DCs) bridge innate and adaptive immune responses by presenting antigens to T cells and releasing a variety of cytokines. Several subsets of DCs can be discriminated that engage specific transcriptional pathways for their development. Basic leucine zipper transcription factor ATF-like 3 (Batf3) is required for the development of classical CD8α\(^{+}\) andAtherosclerosis is the main underlying cause for cardiovascular events such as myocardial infarction and stroke and its development might be influenced by immune cells. Dendritic cells (DCs) bridge innate and adaptive immune responses by presenting antigens to T cells and releasing a variety of cytokines. Several subsets of DCs can be discriminated that engage specific transcriptional pathways for their development. Basic leucine zipper transcription factor ATF-like 3 (Batf3) is required for the development of classical CD8α\(^{+}\) and CD103\(^{+}\) DCs. By crossing mice deficient in Batf3 with atherosclerosis-prone low density lipoprotein receptor (Ldlr\(^{−/-}\))-deficient mice we here aimed to further address the contribution of Batf3-dependent CD8α\(^{+}\) and CD103\(^{+}\) antigen-presenting cells to atherosclerosis. We demonstrate that deficiency in Batf3 entailed mild effects on the immune response in the spleen but did not alter atherosclerotic lesion formation in the aorta or aortic root, nor affected plaque phenotype in low density lipoprotein receptor-deficient mice fed a high fat diet. We thus provide evidence that Batf3-dependent antigen-presenting cells do not have a prominent role in atherosclerosis.show moreshow less

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Metadaten
Author: Jesus Gil-Pulido, Clement Cochain, Malte A. Lippert, Nicole Schneider, Elke Butt, Núria Amézaga, Alma Zernecke
URN:urn:nbn:de:bvb:20-opus-170535
Document Type:Journal article
Faculties:Medizinische Fakultät / Institut für Experimentelle Biomedizin
Language:English
Parent Title (English):PLoS ONE
Year of Completion:2017
Volume:12
Issue:8
Pagenumber:e0181947
Source:PLoS ONE 12(8):e0181947 (2017). DOI: 10.1371/journal.pone.0181947
DOI:https://doi.org/10.1371/journal.pone.0181947
Pubmed Id:http://www.ncbi.nlm.nih.gov/pubmed?term=28771609
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Tag:Batf3; atherosclerosis; deficiency; dendritic cells
Release Date:2019/09/27
Licence (German):License LogoCC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International