Enantioselective microbial reduction of 1,1-dimethyl-1-sila-cyclohexan-2-one with growing cells of the yeast Kloeckera corticis (ATCC 20109)
Please always quote using this URN: urn:nbn:de:bvb:20-opus-64010
- (R)-1,1-Dimethyl-1-sila-cyclohexan-2-ol [(R)-2] was prepared by enantioselective microbial reduction of 1,1-dimethyl-1-sila-cyclohexan-2-one (1) with growing cells of the yeast Kloeckera corticis (ATCC 20109). At a substrate concentration of 0.5 g/1 (temperature 27° C, incubation time 16 h), (R}-2 was obtained on a preparative scale in 60% yield and with an enantiomeric purity of 92% ee. Repeated recrystallization of the biotransformation product from n-hexane raised the enantiomeric purity to 99% ee.
Author: | Reinhold Tacke, H. Hengelsberg, H. Zilch, B. Stumpf |
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URN: | urn:nbn:de:bvb:20-opus-64010 |
Document Type: | Journal article |
Faculties: | Fakultät für Chemie und Pharmazie / Institut für Anorganische Chemie |
Language: | English |
Year of Completion: | 1989 |
Source: | In: Joumal of Organometallic Chemistry (1989) 379, 3, 211-216. |
Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften |
GND Keyword: | Anorganische Chemie |
Release Date: | 2012/02/20 |
Licence (German): | Deutsches Urheberrecht |