Evaluation of point shear wave elastography using acoustic radiation force impulse imaging for longitudinal fibrosis assessment in patients with HBeAg-Negative HBV infection
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- Background: Accurate assessment of hepatic fibrosis in patients with chronic HBeAg-negative Hepatitis B is of crucial importance not only to predict the long-term clinical course, but also to evaluate antiviral therapy indication. The aim of this study was to prospectively assess the utility of point shear wave elastography (pSWE) for longitudinal non-invasive fibrosis assessment in a large cohort of untreated patients with chronic HBeAg-negative hepatitis B virus (HBV) infection. Methods: 407 consecutive patients with HBeAg-negative HBVBackground: Accurate assessment of hepatic fibrosis in patients with chronic HBeAg-negative Hepatitis B is of crucial importance not only to predict the long-term clinical course, but also to evaluate antiviral therapy indication. The aim of this study was to prospectively assess the utility of point shear wave elastography (pSWE) for longitudinal non-invasive fibrosis assessment in a large cohort of untreated patients with chronic HBeAg-negative hepatitis B virus (HBV) infection. Methods: 407 consecutive patients with HBeAg-negative HBV infection who underwent pSWE, transient elastography (TE) as well as laboratory fibrosis markers, including fibrosis index based on four factors (FIB-4), aspartate to platelet ratio index (APRI) and FibroTest, on the same day were prospectively followed up for six years. Patients were classified into one of the three groups: inactive carriers (IC; HBV-DNA <2000 IU/mL and ALT <40 U/L); grey zone group 1 (GZ-1; HBV DNA <2000 IU/mL and ALT >40 U/L); grey zone group 2 (GZ-2; HBV-DNA >2000 IU/mL and ALT <40 U/L). Results: pSWE results were significantly correlated with TE (r = 0.29, p < 0.001) and APRI (r = 0.17; p = 0.005). Median pSWE values did not differ between IC, GZ-1 and GZ-2 patients (p = 0.82, p = 0.17, p = 0.34). During six years of follow-up, median pSWE and TE values did not differ significantly over time (TE: p = 0.27; pSWE: p = 0.05). Conclusion: Our data indicate that pSWE could be useful for non-invasive fibrosis assessment and follow-up in patients with HBeAg-negative chronic HBV infection.…
Autor(en): | Christiana Graf, Antonia Mondorf, Viola Knop, Kai-Henrik Peiffer, Julia Dietz, Julia Friess, Heiner Wedemeyer, Peter Buggisch, Stefan Mauss, Thomas Berg, Michael Rausch, Martin Sprinzl, Hartwig Klinker, Holger Hinrichsen, Jean-Pierre Bronowicki, Sebastian Haag, Dietrich Hüppe, Thomas Lutz, Thierry Poynard, Stefan Zeuzem, Mireen Friedrich-Rust, Christoph Sarrazin, Johannes Vermehren |
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URN: | urn:nbn:de:bvb:20-opus-193916 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Medizinische Klinik und Poliklinik II |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Journal of Clinical Medicine |
ISSN: | 2077-0383 |
Erscheinungsjahr: | 2019 |
Band / Jahrgang: | 8 |
Heft / Ausgabe: | 12 |
Aufsatznummer: | 2101 |
Originalveröffentlichung / Quelle: | Journal of Clinical Medicine (2019) 8:12, 2101. https://doi.org/10.3390/jcm8122101 |
DOI: | https://doi.org/10.3390/jcm8122101 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | APRI; FIB-4; HBV; acoustic radiation force impulse imaging; fibrotest; non-invasive fibrosis assessment; point shear wave elastography; transient elastography |
Datum der Freischaltung: | 29.04.2022 |
Datum der Erstveröffentlichung: | 02.12.2019 |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |