Neuropathology of the posteroinferior occipitotemporal gyrus in children with autism
Please always quote using this URN: urn:nbn:de:bvb:20-opus-117275
- Background: While most neuropathologic studies focus on regions involved in behavioral abnormalities in autism, it is also important to identify whether areas that appear functionally normal are devoid of pathologic alterations. In this study we analyzed the posteroinferior occipitotemporal gyrus, an extrastriate area not considered to be affected in autism. This area borders the fusiform gyrus, which is known to exhibit functional and cellular abnormalities in autism. Findings: No studies have implicated posteroinferior occipitotemporal gyrusBackground: While most neuropathologic studies focus on regions involved in behavioral abnormalities in autism, it is also important to identify whether areas that appear functionally normal are devoid of pathologic alterations. In this study we analyzed the posteroinferior occipitotemporal gyrus, an extrastriate area not considered to be affected in autism. This area borders the fusiform gyrus, which is known to exhibit functional and cellular abnormalities in autism. Findings: No studies have implicated posteroinferior occipitotemporal gyrus dysfunction in autism, leading us to hypothesize that neuropathology would not occur in this area. We indeed observed no significant differences in pyramidal neuron number or size in layers III, V, and VI in seven pairs of autism and controls. Conclusions: These findings are consistent with the hypothesis that neuropathology is unique to areas involved in stereotypies and social and emotional behaviors, and support the specificity of the localization of pathology in the fusiform gyrus.…
Author: | Neha Uppal, Isabella Gianatiempo, Bridget Wicinski, James Schmeidler, Helmut Heinsen, Christoph Schmitz, Joseph D. Buxbaum, Patrick R. Hof |
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URN: | urn:nbn:de:bvb:20-opus-117275 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie |
Language: | English |
Parent Title (English): | Molecular Autism |
Year of Completion: | 2014 |
Volume: | 5 |
Issue: | 17 |
Source: | Molecular Autism 2014, 5:17. doi:10.1186/2040-2392-5-17 |
DOI: | https://doi.org/10.1186/2040-2392-5-17 |
Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/24564936 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | Stereology; autism; fusiform gyrus; neuropathology; posteroinferior occipitotemporal gyrus; sections |
Release Date: | 2015/08/17 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung |