Mitochondria as therapeutic targets in heart failure
Please always quote using this URN: urn:nbn:de:bvb:20-opus-324015
- Purpose of Review We review therapeutic approaches aimed at restoring function of the failing heart by targeting mitochondrial reactive oxygen species (ROS), ion handling, and substrate utilization for adenosine triphosphate (ATP) production. Recent Findings Mitochondria-targeted therapies have been tested in animal models of and humans with heart failure (HF). Cardiac benefits of sodium/glucose cotransporter 2 inhibitors might be partly explained by their effects on ion handling and metabolism of cardiac myocytes. Summary The largePurpose of Review We review therapeutic approaches aimed at restoring function of the failing heart by targeting mitochondrial reactive oxygen species (ROS), ion handling, and substrate utilization for adenosine triphosphate (ATP) production. Recent Findings Mitochondria-targeted therapies have been tested in animal models of and humans with heart failure (HF). Cardiac benefits of sodium/glucose cotransporter 2 inhibitors might be partly explained by their effects on ion handling and metabolism of cardiac myocytes. Summary The large energy requirements of the heart are met by oxidative phosphorylation in mitochondria, which is tightly regulated by the turnover of ATP that fuels cardiac contraction and relaxation. In heart failure (HF), this mechano-energetic coupling is disrupted, leading to bioenergetic mismatch and production of ROS that drive the progression of cardiac dysfunction. Furthermore, HF is accompanied by changes in substrate uptake and oxidation that are considered detrimental for mitochondrial oxidative metabolism and negatively affect cardiac efficiency. Mitochondria lie at the crossroads of metabolic and energetic dysfunction in HF and represent ideal therapeutic targets.…
Author: | Julia Schwemmlein, Christoph Maack, Edoardo Bertero |
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URN: | urn:nbn:de:bvb:20-opus-324015 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Deutsches Zentrum für Herzinsuffizienz (DZHI) |
Language: | English |
Parent Title (English): | Current Heart Failure Reports |
Year of Completion: | 2022 |
Volume: | 19 |
Issue: | 2 |
Pagenumber: | 27-37 |
Source: | Current Heart Failure Reports (2022) 19:2, 27-37 DOI: 10.1007/s11897-022-00539-0 |
DOI: | https://doi.org/10.1007/s11897-022-00539-0 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | MitoQ; SGLT2 inhibitors; cardiac metabolism; elamipretide; heart failure; mitochondria; reactive oxygen species |
Release Date: | 2024/01/17 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |