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Analysis of fenoterol and ipratropium transfer from human lung tissue into human plasma using a dynamic dialysis model
Please always quote using this URN: urn:nbn:de:bvb:20-opus-120231
- Aims: The aim of the current study was to establish a simple and yet as much as possible physiologic approach for a simulation of the pulmonary absorption process to compare different inhaled drugs or drug formulations. Methodology: We designed a dialysis setting that allowed monitoring the drug release from human lung tissue into a continuous-flow plasma compartment. For proof-of-concept experiments we chose the glucocorticoid fluticasone propionate (FP) as model compound. For subsequent experiments we selected a commercially availableAims: The aim of the current study was to establish a simple and yet as much as possible physiologic approach for a simulation of the pulmonary absorption process to compare different inhaled drugs or drug formulations. Methodology: We designed a dialysis setting that allowed monitoring the drug release from human lung tissue into a continuous-flow plasma compartment. For proof-of-concept experiments we chose the glucocorticoid fluticasone propionate (FP) as model compound. For subsequent experiments we selected a commercially available metered dose inhaler delivering a fixed combination of the short-acting ß2-agonist fenoterol and the muscarinic antagonist ipratropium bromide. Results: With the novel dynamic dialysis model we observed high drug transport rates from the lung tissue into plasma including an elimination phase. The concentration profile in the plasma compartment of our model system was similar to the plasma concentration courses after inhalation of FP. Compared to FP significantly higher drug fractions of fenoterol and ipratropium bromide were released into plasma and the transfer of ipratropium was more pronounced compared to fenoterol. Again, concentration profiles in plasma were alike to those described in clinical studies. Conclusion: We suggest that this model is appropriate for rapid assessment of comparative diffusion behaviour of drugs or drug formulations from lung tissue into plasma.…
Author: | Beatrice Trammer, Boris Kardziev, Michael Schmidt, P. Hoegger |
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URN: | urn:nbn:de:bvb:20-opus-120231 |
Document Type: | Journal article |
Faculties: | Fakultät für Chemie und Pharmazie / Institut für Pharmazie und Lebensmittelchemie |
Language: | English |
Parent Title (English): | British Journal of Pharmaceutical Research |
Year of Completion: | 2014 |
Volume: | 4 |
Issue: | 11 |
Pagenumber: | 1287-1299 |
Source: | British Journal of Pharmaceutical Research 4(11): 1287-1299, 2014 |
DOI: | https://doi.org/10.9734/BJPR/2014/9993 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | bronchial tissue; fenoterol; fluticasone propionate; human; ipratropium bromide; pulmonary absorption |
Release Date: | 2016/02/11 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung |