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Shaped by leaky ER: Homeostatic Ca\(^{2+}\) fluxes
Please always quote using this URN: urn:nbn:de:bvb:20-opus-287102
- At any moment in time, cells coordinate and balance their calcium ion (Ca\(^{2+}\)) fluxes. The term ‘Ca\(^{2+}\) homeostasis’ suggests that balancing resting Ca2+ levels is a rather static process. However, direct ER Ca\(^{2+}\) imaging shows that resting Ca\(^{2+}\) levels are maintained by surprisingly dynamic Ca\(^{2+}\) fluxes between the ER Ca\(^{2+}\) store, the cytosol, and the extracellular space. The data show that the ER Ca\(^{2+}\) leak, continuously fed by the high-energy consuming SERCA, is a fundamental driver of restingAt any moment in time, cells coordinate and balance their calcium ion (Ca\(^{2+}\)) fluxes. The term ‘Ca\(^{2+}\) homeostasis’ suggests that balancing resting Ca2+ levels is a rather static process. However, direct ER Ca\(^{2+}\) imaging shows that resting Ca\(^{2+}\) levels are maintained by surprisingly dynamic Ca\(^{2+}\) fluxes between the ER Ca\(^{2+}\) store, the cytosol, and the extracellular space. The data show that the ER Ca\(^{2+}\) leak, continuously fed by the high-energy consuming SERCA, is a fundamental driver of resting Ca\(^{2+}\) dynamics. Based on simplistic Ca\(^{2+}\) toolkit models, we discuss how the ER Ca\(^{2+}\) leak could contribute to evolutionarily conserved Ca\(^{2+}\) phenomena such as Ca\(^{2+}\) entry, ER Ca\(^{2+}\) release, and Ca\(^{2+}\) oscillations.…
Author: | Annemarie Schulte, Robert Blum |
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URN: | urn:nbn:de:bvb:20-opus-287102 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Neurologische Klinik und Poliklinik |
Medizinische Fakultät / Klinik und Poliklinik für Anästhesiologie (ab 2004) | |
Language: | English |
Parent Title (English): | Frontiers in Physiology |
ISSN: | 1664-042X |
Year of Completion: | 2022 |
Volume: | 13 |
Article Number: | 972104 |
Source: | Frontiers in Physiology (2022) 13:972104. doi: 10.3389/fphys.2022.972104 |
DOI: | https://doi.org/10.3389/fphys.2022.972104 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | Ca2+ homeostasis; Ca2+ ion analysis; Ca2+ leak; Ca2+ oscillation; ER Ca2+ imaging; ER Ca2+ store; SERCA; store-operated Ca2+ entry |
Release Date: | 2023/04/19 |
Date of first Publication: | 2022/09/07 |
Open-Access-Publikationsfonds / Förderzeitraum 2022 | |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |