The role of polymorphisms at the Interleukin-1, Interleukin-4, GATA-3 and Cyclooxygenase-2 genes in non-surgical periodontal therapy
Please always quote using this URN: urn:nbn:de:bvb:20-opus-284386
- Periodontitis is a multifactorial disease. The aim of this explorative study was to investigate the role of Interleukin-(IL)-1, IL-4, GATA-3 and Cyclooxygenase-(COX)-2 polymorphisms after non-surgical periodontal therapy with adjunctive systemic antibiotics (amoxicillin/metronidazole) and subsequent maintenance in a Caucasian population. Analyses were performed using blood samples from periodontitis patients of a multi-center trial (ClinicalTrials.gov NCT00707369=ABPARO-study). Polymorphisms were analyzed using quantitative real-time PCR.Periodontitis is a multifactorial disease. The aim of this explorative study was to investigate the role of Interleukin-(IL)-1, IL-4, GATA-3 and Cyclooxygenase-(COX)-2 polymorphisms after non-surgical periodontal therapy with adjunctive systemic antibiotics (amoxicillin/metronidazole) and subsequent maintenance in a Caucasian population. Analyses were performed using blood samples from periodontitis patients of a multi-center trial (ClinicalTrials.gov NCT00707369=ABPARO-study). Polymorphisms were analyzed using quantitative real-time PCR. Clinical attachment levels (CAL), percentage of sites showing further attachment loss (PSAL) ≥1.3 mm, bleeding on probing (BOP) and plaque score were assessed. Exploratory statistical analysis was performed. A total of 209 samples were genotyped. Patients carrying heterozygous genotypes and single-nucleotide-polymorphisms (SNP) on the GATA-3-IVS4 +1468 gene locus showed less CAL loss than patients carrying wild type. Heterozygous genotypes and SNPs on the IL-1A-889, IL-1B +3954, IL-4-34, IL-4-590, GATA-3-IVS4 +1468 and COX-2-1195 gene loci did not influence CAL. In multivariate analysis, CAL was lower in patients carrying GATA-3 heterozygous genotypes and SNPs than those carrying wild-types. For the first time, effects of different genotypes were analyzed in periodontitis progression after periodontal therapy and during supportive treatment using systemic antibiotics demonstrating a slight association of GATA-3 gene locus with CAL. This result suggests that GATA-3 genotypes are a contributory but non-essential risk factor for periodontal disease progression.…
Author: | Kay-Arne Walther, José Roberto Gonzales, Sabine Gröger, Benjamin Ehmke, Dogan Kaner, Katrin Lorenz, Peter Eickholz, Thomas Kocher, Ti-Sun Kim, Ulrich Schlagenhauf, Raphael Koch, Jörg Meyle |
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URN: | urn:nbn:de:bvb:20-opus-284386 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Abteilung für Parodontologie (in der Poliklinik für Zahnerhaltung und Parodontologie) |
Language: | English |
Parent Title (English): | International Journal of Molecular Sciences |
ISSN: | 1422-0067 |
Year of Completion: | 2022 |
Volume: | 23 |
Issue: | 13 |
Article Number: | 7266 |
Source: | International Journal of Molecular Sciences (2022), 23:13, 7266. https://doi.org/10.3390/ijms23137266 |
DOI: | https://doi.org/10.3390/ijms23137266 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | Cyclooxygenase-2; GATA-3; Interleukin-1; Interleukin-4; antibiotics; periodontal therapy; periodontitis; polymorphisms; risk factor |
Release Date: | 2023/05/30 |
Date of first Publication: | 2022/06/30 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |