The influence of capsaicin on the integrity of microvascular endothelial cell monolayers
Please always quote using this URN: urn:nbn:de:bvb:20-opus-284865
- Microvascular endothelial cells are an essential part of many biological barriers, such as the blood–brain barrier (BBB) and the endothelium of the arteries and veins. A reversible opening strategy to increase the permeability of drugs across the BBB could lead to improved therapies due to enhanced drug bioavailability. Vanilloids, such as capsaicin, are known to reversibly open tight junctions of epithelial and endothelial cells. In this study, we used several in vitro assays with the murine endothelial capillary brain cells (line cEND) as aMicrovascular endothelial cells are an essential part of many biological barriers, such as the blood–brain barrier (BBB) and the endothelium of the arteries and veins. A reversible opening strategy to increase the permeability of drugs across the BBB could lead to improved therapies due to enhanced drug bioavailability. Vanilloids, such as capsaicin, are known to reversibly open tight junctions of epithelial and endothelial cells. In this study, we used several in vitro assays with the murine endothelial capillary brain cells (line cEND) as a BBB model to characterize the interaction between capsaicin and endothelial tight junctions.…
Author: | Mathias Kaiser, Malgorzata Burek, Stefan Britz, Frauke Lankamp, Steffi Ketelhut, Björn Kemper, Carola Förster, Christian Gorzelanny, Francisco M. Goycoolea |
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URN: | urn:nbn:de:bvb:20-opus-284865 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Klinik und Poliklinik für Anästhesiologie (ab 2004) |
Language: | English |
Parent Title (English): | International Journal of Molecular Sciences |
ISSN: | 1422-0067 |
Year of Completion: | 2018 |
Volume: | 20 |
Issue: | 1 |
Article Number: | 122 |
Source: | International Journal of Molecular Sciences (2019) 20:1, 122. https://doi.org/10.3390/ijms20010122 |
DOI: | https://doi.org/10.3390/ijms20010122 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | capsaicin; endothelial cells; tight junctions |
Release Date: | 2023/06/05 |
Date of first Publication: | 2018/12/30 |
EU-Project number / Contract (GA) number: | 613931 |
OpenAIRE: | OpenAIRE |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |