Endothelial–platelet interactions in influenza‐induced pneumonia: A potential therapeutic target
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- Every year, influenza viruses spread around the world, infecting the respiratory systems of countless humans and animals, causing illness and even death. Severe influenza infection is associated with pulmonary epithelial damage and endothelial dysfunction leading to acute lung injury (ALI). There is evidence that an aggressive cytokine storm and cell damage in lung capillaries as well as endothelial/platelet interactions contribute to vascular leakage, pro‐thrombotic milieu and infiltration of immune effector cells. To date, treatments for ALIEvery year, influenza viruses spread around the world, infecting the respiratory systems of countless humans and animals, causing illness and even death. Severe influenza infection is associated with pulmonary epithelial damage and endothelial dysfunction leading to acute lung injury (ALI). There is evidence that an aggressive cytokine storm and cell damage in lung capillaries as well as endothelial/platelet interactions contribute to vascular leakage, pro‐thrombotic milieu and infiltration of immune effector cells. To date, treatments for ALI caused by influenza are limited to antiviral drugs, active ventilation or further symptomatic treatments. In this review, we summarize the mechanisms of influenza‐mediated pathogenesis, permissive animal models and histopathological changes of lung tissue in both mice and men and compare it with histological and electron microscopic data from our own group. We highlight the molecular and cellular interactions between pulmonary endothelium and platelets in homeostasis and influenza‐induced pathogenesis. Finally, we discuss novel therapeutic targets on platelets/endothelial interaction to reduce or resolve ALI.…
Autor(en): | Marcel G. E. Rommel, Christian Milde, Regina Eberle, Harald Schulze, Ute Modlich |
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URN: | urn:nbn:de:bvb:20-opus-213610 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Institut für Experimentelle Biomedizin |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Anatomia, Histologia, Embryologia |
Erscheinungsjahr: | 2020 |
Band / Jahrgang: | 49 |
Heft / Ausgabe: | 5 |
Erste Seite: | 606 |
Letzte Seite: | 619 |
Originalveröffentlichung / Quelle: | Anatomia, Histologia, Embryologia 2020, 49(5):606–619. DOI: 10.1111/ahe.12521 |
DOI: | https://doi.org/10.1111/ahe.12521 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | endothelial cell; influenza; interaction; laboratory animals; lung injury; platelet; pneumonia; therapy |
Datum der Freischaltung: | 01.04.2021 |
Lizenz (Deutsch): | CC BY-NC-ND: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell, Keine Bearbeitungen 4.0 International |