Current Understanding of Nasal Epithelial Cell Mis-Differentiation
Please always quote using this URN: urn:nbn:de:bvb:20-opus-228562
- The functional role of the respiratory epithelium is to generate a physical barrier. In addition, the epithelium supports the innate and acquired immune system through various cytokines and chemokines. However, epithelial cells are also involved in the pathogenesis of various respiratory diseases, some of which are mediated by increased permeability of the mucosal membrane or disturbed mucociliary transport. In addition, it has been shown that epithelial cells are involved in the development of inflammatory respiratory diseases. The followingThe functional role of the respiratory epithelium is to generate a physical barrier. In addition, the epithelium supports the innate and acquired immune system through various cytokines and chemokines. However, epithelial cells are also involved in the pathogenesis of various respiratory diseases, some of which are mediated by increased permeability of the mucosal membrane or disturbed mucociliary transport. In addition, it has been shown that epithelial cells are involved in the development of inflammatory respiratory diseases. The following review article focuses on the aspects of epithelial mis-differentiation, in particular with respect to nasal mucosal barrier function, epithelial immunogenicity, nasal epithelial-mesenchymal transition and nasal microbiome.…
Author: | Agmal Scherzad, Rudolf Hagen, Stephan Hackenberg |
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URN: | urn:nbn:de:bvb:20-opus-228562 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Augenklinik und Poliklinik |
Language: | English |
Parent Title (English): | Journal of Inflammation Research |
Year of Completion: | 2019 |
Volume: | 12 |
Pagenumber: | 309-317 |
Source: | Journal of Inflammation Research 2019:12 309–317 |
DOI: | https://doi.org/10.2147/JIR.S180853 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | epithelial-mesenchymal transition; microbiome; nasal mucosal barrier function; tight junction |
Release Date: | 2021/11/02 |
Licence (German): | CC BY-NC: Creative-Commons-Lizenz: Namensnennung, Nicht kommerziell |