Diversity of Nonribosomal Peptide Synthetase Genes in the Microbial Metagenomes of Marine Sponges
Please always quote using this URN: urn:nbn:de:bvb:20-opus-75990
- Genomic mining revealed one major nonribosomal peptide synthetase (NRPS) phylogenetic cluster in 12 marine sponge species, one ascidian, an actinobacterial isolate and seawater. Phylogenetic analysis predicts its taxonomic affiliation to the actinomycetes and hydroxy-phenyl-glycine as a likely substrate. Additionally, a phylogenetically distinct NRPS gene cluster was discovered in the microbial metagenome of the sponge Aplysina aerophoba, which shows highest similarities to NRPS genes that were previously assigned, by ways of single cellGenomic mining revealed one major nonribosomal peptide synthetase (NRPS) phylogenetic cluster in 12 marine sponge species, one ascidian, an actinobacterial isolate and seawater. Phylogenetic analysis predicts its taxonomic affiliation to the actinomycetes and hydroxy-phenyl-glycine as a likely substrate. Additionally, a phylogenetically distinct NRPS gene cluster was discovered in the microbial metagenome of the sponge Aplysina aerophoba, which shows highest similarities to NRPS genes that were previously assigned, by ways of single cell genomics, to a Chloroflexi sponge symbiont. Genomic mining studies such as the one presented here for NRPS genes, contribute to on-going efforts to characterize the genomic potential of sponge-associated microbiota for secondary metabolite biosynthesis.…
Author: | Sheila Marie Pimentel-Elardo, Lubomir Grozdanov, Sebastian Proksch, Ute Hentschel |
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URN: | urn:nbn:de:bvb:20-opus-75990 |
Document Type: | Journal article |
Faculties: | Fakultät für Biologie / Julius-von-Sachs-Institut für Biowissenschaften |
Language: | English |
Year of Completion: | 2012 |
Source: | In: Marine Drugs (2012) 10, 1192-1202, doi:10.3390/md10061192 |
Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 58 Pflanzen (Botanik) / 580 Pflanzen (Botanik) |
GND Keyword: | Biologie |
Tag: | NRPS; Porifera; marine sponge; metagenomics; nonribosomal peptide synthetase |
Release Date: | 2013/04/17 |
Collections: | Open-Access-Publikationsfonds / Förderzeitraum 2012 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung |