- search hit 1 of 1
Drug excretion mediated by a new prototype of polyspecific transporter
Please always quote using this URN: urn:nbn:de:bvb:20-opus-59327
- CATIO~IC drugs of different types and structures (antihistaminics, antiarrhythmics, sedatives, opiates, cytostatics and antibiotics, for example) are excreted in mammals by epithelial cells of the renal proximal tubules and by hepatocytes in the liver<sup>1-4</sup>. In the proximal tubules, two functionally disparate transport systems are involved which are localized in the basolateral and luminal plasma membrane and are different from the previously identified neuronal monoamine transporters and A TP-dependent multidrug exportingCATIO~IC drugs of different types and structures (antihistaminics, antiarrhythmics, sedatives, opiates, cytostatics and antibiotics, for example) are excreted in mammals by epithelial cells of the renal proximal tubules and by hepatocytes in the liver<sup>1-4</sup>. In the proximal tubules, two functionally disparate transport systems are involved which are localized in the basolateral and luminal plasma membrane and are different from the previously identified neuronal monoamine transporters and A TP-dependent multidrug exporting proteins<sup>1-3,5-12</sup>. Here we report the isolation of a complementary DNA from rat kidney that encodes a 556-amino-acid membrane protein, OCT1, which has the functional characteristics of organic cation uptake over the basolateral membrane of renal proximal tubules and of organic cation uptake into hepatocytes. OCTl is not homologous to any other known protein and is found in kidney, liver and intestine. As OCTl translocates hydrophobic and hydrophilic organic cations of different structures, it is considered to be a new prolotype of polyspecific transporters that are important for drug elimination.…
Author: | Dirk Gründemann, Valentin Gorboulev, Stepan Gambaryan, Maike Veyhl, Hermann Koepsell |
---|---|
URN: | urn:nbn:de:bvb:20-opus-59327 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Institut für Anatomie und Zellbiologie |
Language: | English |
Year of Completion: | 1994 |
Source: | In: Nature (1994) 372, S. 549 - 552. |
Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie |
GND Keyword: | Biologie |
Release Date: | 2011/08/10 |
Licence (German): | Deutsches Urheberrecht |