Suspected metastatic adrenocortical carcinoma revealing as pulmonary Kaposi sarcoma in adrenal Cushing’s syndrome
Please always quote using this URN: urn:nbn:de:bvb:20-opus-110553
- Background Kaposi sarcoma (KS) is a malignant disease most commonly diagnosed in the setting of a human immunodeficiency virus (HIV) infection and in patients receiving immunosuppressive treatment. Pulmonary KS has never been reported in association with endogenous Cushing’s syndrome (CS). Case presentation A 60-year-old woman presented with symptoms and signs of CS. Adrenal CS was confirmed by standard biochemical evaluation. Imaging revealed a right adrenal lesion (diameter 3.5 cm) and multiple pulmonary nodules, suggesting aBackground Kaposi sarcoma (KS) is a malignant disease most commonly diagnosed in the setting of a human immunodeficiency virus (HIV) infection and in patients receiving immunosuppressive treatment. Pulmonary KS has never been reported in association with endogenous Cushing’s syndrome (CS). Case presentation A 60-year-old woman presented with symptoms and signs of CS. Adrenal CS was confirmed by standard biochemical evaluation. Imaging revealed a right adrenal lesion (diameter 3.5 cm) and multiple pulmonary nodules, suggesting a cortisol-secreting adrenal carcinoma with pulmonary metastases. The patient underwent right adrenalectomy with a pathohistological diagnosis of an adrenal adenoma. Subsequent thoracoscopic wedge resection of one lung lesion revealed pulmonary KS with positive immunostaining for human herpes virus 8 (HHV-8). HIV-serology was negative. Hydrocortisone replacement was initiated for secondary adrenal insufficiency after surgery. Post-operative follow up imaging showed complete remission of all KS-related pulmonary nodules solely after resolution of hypercortisolism. Conclusion KS may occur in the setting of endogenous CS and may go into remission after cure of hypercortisolism without further specific treatment.…
Author: | Margarita Bala, Cristina L. Ronchi, Josef Pichl, Vanessa Wild, Stefan Kircher, Bruno Allolio, Stefanie Hahner |
---|---|
URN: | urn:nbn:de:bvb:20-opus-110553 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Pathologisches Institut |
Medizinische Fakultät / Medizinische Klinik und Poliklinik I | |
Language: | English |
Year of Completion: | 2014 |
Source: | BMC Endocrine Disorders 2014, 14:63. doi:10.1186/1472-6823-14-63 |
DOI: | https://doi.org/10.1186/1472-6823-14-63 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | Cushing’s syndrome; Hypercortisolism; Immunosuppression; Kaposi sarcoma |
Release Date: | 2015/03/04 |
Collections: | Open-Access-Publikationsfonds / Förderzeitraum 2014 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung |