Platelets as modulators of cerebral ischemia/reperfusion injury
Please always quote using this URN: urn:nbn:de:bvb:20-opus-195748
- Ischemic stroke is among the leading causes of disability and death worldwide. In acute ischemic stroke, the rapid recanalization of occluded cranial vessels is the primary therapeutic aim. However, experimental data (obtained using mostly the transient middle cerebral artery occlusion model) indicates that progressive stroke can still develop despite successful recanalization, a process termed “reperfusion injury.” Mounting experimental evidence suggests that platelets and T cells contribute to cerebral ischemia/reperfusion injury, andIschemic stroke is among the leading causes of disability and death worldwide. In acute ischemic stroke, the rapid recanalization of occluded cranial vessels is the primary therapeutic aim. However, experimental data (obtained using mostly the transient middle cerebral artery occlusion model) indicates that progressive stroke can still develop despite successful recanalization, a process termed “reperfusion injury.” Mounting experimental evidence suggests that platelets and T cells contribute to cerebral ischemia/reperfusion injury, and ischemic stroke is increasingly considered a thrombo-inflammatory disease. The interaction of von Willebrand factor and its receptor on the platelet surface, glycoprotein Ib, as well as many activatory platelet receptors and platelet degranulation contribute to secondary infarct growth in this setting. In contrast, interference with GPIIb/IIIa-dependent platelet aggregation and thrombus formation does not improve the outcome of acute brain ischemia but dramatically increases the susceptibility to intracranial hemorrhage. Here, we summarize the current understanding of the mechanisms and the potential translational impact of platelet contributions to cerebral ischemia/reperfusion injury.…
Author: | David Stegner, Vanessa Klaus, Bernhard Nieswandt |
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URN: | urn:nbn:de:bvb:20-opus-195748 |
Document Type: | Journal article |
Faculties: | Fakultät für Biologie / Rudolf-Virchow-Zentrum |
Medizinische Fakultät / Institut für Experimentelle Biomedizin | |
Language: | English |
Parent Title (English): | Frontiers in Immunology |
ISSN: | 1664-3224 |
Year of Completion: | 2019 |
Volume: | 10 |
Issue: | 2505 |
Source: | Frontiers in Immunology 10:2505. doi: 10.3389/fimmu.2019.02505 |
DOI: | https://doi.org/10.3389/fimmu.2019.02505 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | glycoprotein Ibα; ischemic stroke; platelet; platelet degranulation; thrombo-inflammation |
Release Date: | 2020/03/02 |
Date of first Publication: | 2019/11/01 |
Open-Access-Publikationsfonds / Förderzeitraum 2019 | |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |