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An experimental protocol for mimicking pathomechanisms of traumatic brain injury in mice
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-75368
- Traumatic brain injury (TBI) is a result of an outside force causing immediate mechanical disruption of brain tissue and delayed pathogenic events. In order to examine injury processes associated with TBI, a number of rodent models to induce brain trauma have been described. However, none of these models covers the entire spectrum of events that might occur in TBI. Here we provide a thorough methodological description of a straightforward closed head weight drop mouse model to assess brain injuries close to the clinical conditions of human TBI.Traumatic brain injury (TBI) is a result of an outside force causing immediate mechanical disruption of brain tissue and delayed pathogenic events. In order to examine injury processes associated with TBI, a number of rodent models to induce brain trauma have been described. However, none of these models covers the entire spectrum of events that might occur in TBI. Here we provide a thorough methodological description of a straightforward closed head weight drop mouse model to assess brain injuries close to the clinical conditions of human TBI.…
Autor(en): | Christiane Albert-Weißenberger, Csanád Várrallyay, Furat Raslan, Christoph Kleinschnitz, Anna-Leena Sirén |
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URN: | urn:nbn:de:bvb:20-opus-75368 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Neurologische Klinik und Poliklinik |
Sprache der Veröffentlichung: | Englisch |
Erscheinungsjahr: | 2012 |
Originalveröffentlichung / Quelle: | In: Experimental & Translational Stroke Medicine (2012) 4: 1, doi:10.1186/2040-7378-4-1 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Normierte Schlagworte (GND): | Medizin |
Freie Schlagwort(e): | astrocyte; closed head injury; microglia; neurobehavioural deficits; neurons; traumatic brain injury |
Datum der Freischaltung: | 25.03.2013 |
Sammlungen: | Open-Access-Publikationsfonds / Förderzeitraum 2012 |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung |