Covalent binding of ethinylestradiol and estrone to rat liver DNA in vivo
Please always quote using this URN: urn:nbn:de:bvb:20-opus-61162
- Thecovalent bindingof [6,7-\(^3\)H]ethinylestradiol (EE)and [6,7-\(^3\)H]estrone (E) to liver DNA of 200 g female ratswas measured 8 h after the administration of 80 \(\mu\)g (9.2 mCi) estrogen by gavage. The binding is 1.5 for EE and 1.1 for E, expressedas binding to DNA/dose, in units of \(\mu\)mol hormonefmol DNA phosphate/mmole honnone/kg body wt. It is in the same order of magnitude as for benzene and about 10 000 tim es below the binding of typical liver carcinogens, such as aflatoxin B\(_1\) or N,N-dimethylnitrosamine.
Author: | W. Jaggi, Werner K. Lutz, C. Schlatter |
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URN: | urn:nbn:de:bvb:20-opus-61162 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Institut für Pharmakologie und Toxikologie |
Language: | English |
Year of Completion: | 1978 |
Source: | Chemico-Biological Interactions (1978) 23, 1, 13-8. |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
GND Keyword: | Toxikologie |
Release Date: | 2012/01/27 |
Licence (German): | Deutsches Urheberrecht |