Health behavior and cancer prevention among adults with Li-Fraumeni syndrome and relatives in Germany — a cohort description
Please always quote using this URN: urn:nbn:de:bvb:20-opus-290432
- Li-Fraumeni-syndrome (LFS) is a rare, highly penetrant cancer predisposition syndrome (CPS) caused by pathogenic variants (PVs) in TP53. Physical activity (PA) and a Mediterranean diet lead to cancer reduction or survival benefits and increased quality of life (QoL), but this is yet unstudied among LFS. TP53 PV carriers (PVC) and their relatives were questioned on dietary patterns (Mediterranean Diet Adherence Screener), PA (Freiburg Questionnaire), QoL (Short-form-Health-Survey-12), smoking, alcohol consumption and perception of cancer risk inLi-Fraumeni-syndrome (LFS) is a rare, highly penetrant cancer predisposition syndrome (CPS) caused by pathogenic variants (PVs) in TP53. Physical activity (PA) and a Mediterranean diet lead to cancer reduction or survival benefits and increased quality of life (QoL), but this is yet unstudied among LFS. TP53 PV carriers (PVC) and their relatives were questioned on dietary patterns (Mediterranean Diet Adherence Screener), PA (Freiburg Questionnaire), QoL (Short-form-Health-Survey-12), smoking, alcohol consumption and perception of cancer risk in a German bi-centric study from March 2020–June 2021. The study enrolled 70 PVC and 43 relatives. Women compared to men (6.49 vs. 5.38, p = 0.005) and PVC to relatives (6.59 vs. 5.51; p = 0.006) showed a healthier diet, associated with participation in surveillance (p = 0.04) and education (diet p = 0.02 smoking p = 0.0003). Women smoked less (2.91 vs. 5.91 packyears; p = 0.03), psychological well-being was higher among men (SF-12: males 48.06 vs. females 41.94; p = 0.004). PVC rated their own cancer risk statistically higher than relatives (72% vs. 38%, p < 0.001) however, cancer risk of the general population was rated lower (38% vs. 70%, p < 0.001). A relative’s cancer-related death increased the estimated personal cancer risk (p = 0.01). The possibilities of reducing cancer through self-determined health behavior among PVC and relatives has not yet been exhausted. Educating families with a CPS on cancer-preventive behavior requires further investigation with regard to acceptance and real-life implementation.…
| Author: | Juliane Nees, Senta Kiermeier, Farina Struewe, Myriam Keymling, Imad Maatouk, Christian P. Kratz, Sarah Schott |
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| URN: | urn:nbn:de:bvb:20-opus-290432 |
| Document Type: | Journal article |
| Faculties: | Medizinische Fakultät / Medizinische Klinik und Poliklinik II |
| Language: | English |
| Parent Title (English): | Current Oncology |
| ISSN: | 1718-7729 |
| Year of Completion: | 2022 |
| Volume: | 29 |
| Issue: | 10 |
| First Page: | 7768 |
| Last Page: | 7778 |
| Source: | Current Oncology (2022) 29:10, 7768-7778. https://doi.org/10.3390/curroncol29100614 |
| DOI: | https://doi.org/10.3390/curroncol29100614 |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Tag: | Li-Fraumeni syndrome; MEDAS; SF-12; cancer predisposition; cancer prevention; pathogenic TP53 germline variant; physical activity |
| Release Date: | 2023/10/27 |
| Date of first Publication: | 2022/10/15 |
| Licence (German): |  CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |