Small RNA functions in carbon metabolism and virulence of enteric pathogens
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-197520
- Enteric pathogens often cycle between virulent and saprophytic lifestyles. To endure these frequent changes in nutrient availability and composition bacteria possess an arsenal of regulatory and metabolic genes allowing rapid adaptation and high flexibility. While numerous proteins have been characterized with regard to metabolic control in pathogenic bacteria, small non-coding RNAs have emerged as additional regulators of metabolism. Recent advances in sequencing technology have vastly increased the number of candidate regulatory RNAs andEnteric pathogens often cycle between virulent and saprophytic lifestyles. To endure these frequent changes in nutrient availability and composition bacteria possess an arsenal of regulatory and metabolic genes allowing rapid adaptation and high flexibility. While numerous proteins have been characterized with regard to metabolic control in pathogenic bacteria, small non-coding RNAs have emerged as additional regulators of metabolism. Recent advances in sequencing technology have vastly increased the number of candidate regulatory RNAs and several of them have been found to act at the interface of bacterial metabolism and virulence factor expression. Importantly, studying these riboregulators has not only provided insight into their metabolic control functions but also revealed new mechanisms of post-transcriptional gene control. This review will focus on the recent advances in this area of host-microbe interaction and discuss how regulatory small RNAs may help coordinate metabolism and virulence of enteric pathogens.…
Autor(en): | Kai Papenfort, Jörg Vogel |
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URN: | urn:nbn:de:bvb:20-opus-197520 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Institut für Molekulare Infektionsbiologie |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Frontiers in Cellular and Infection Microbiology |
ISSN: | 2235-2988 |
Erscheinungsjahr: | 2014 |
Band / Jahrgang: | 4 |
Heft / Ausgabe: | 91 |
Originalveröffentlichung / Quelle: | Frontiers in Cellular and Infection Microbiology (2014) 4:91. doi: 10.3389/fcimb.2014.00091 |
DOI: | https://doi.org/10.3389/fcimb.2014.00091 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | CsrA; Hfq; carbon metabolism; sRNA; virulence |
Datum der Freischaltung: | 10.08.2020 |
Datum der Erstveröffentlichung: | 15.07.2014 |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung |