Short-chain fatty acids in Chronic Kidney Disease: focus on inflammation and oxidative stress regulation
Please always quote using this URN: urn:nbn:de:bvb:20-opus-284587
- Chronic Kidney Disease (CKD) is a debilitating disease associated with several secondary complications that increase comorbidity and mortality. In patients with CKD, there is a significant qualitative and quantitative alteration in the gut microbiota, which, consequently, also leads to reduced production of beneficial bacterial metabolites, such as short-chain fatty acids. Evidence supports the beneficial effects of short-chain fatty acids in modulating inflammation and oxidative stress, which are implicated in CKD pathogenesis and progression.Chronic Kidney Disease (CKD) is a debilitating disease associated with several secondary complications that increase comorbidity and mortality. In patients with CKD, there is a significant qualitative and quantitative alteration in the gut microbiota, which, consequently, also leads to reduced production of beneficial bacterial metabolites, such as short-chain fatty acids. Evidence supports the beneficial effects of short-chain fatty acids in modulating inflammation and oxidative stress, which are implicated in CKD pathogenesis and progression. Therefore, this review will provide an overview of the current knowledge, based on pre-clinical and clinical evidence, on the effect of SCFAs on CKD-associated inflammation and oxidative stress.…
Author: | Giorgia Magliocca, Pasquale Mone, Biagio Raffaele Di Iorio, August Heidland, Stefania Marzocco |
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URN: | urn:nbn:de:bvb:20-opus-284587 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Medizinische Klinik und Poliklinik I |
Language: | English |
Parent Title (English): | International Journal of Molecular Sciences |
ISSN: | 1422-0067 |
Year of Completion: | 2022 |
Volume: | 23 |
Issue: | 10 |
Article Number: | 5354 |
Source: | International Journal of Molecular Sciences (2022) 23:10, 5354. https://doi.org/10.3390/ijms23105354 |
DOI: | https://doi.org/10.3390/ijms23105354 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | chronic kidney disease; inflammation; oxidative stress; short-chain fatty acids; uremic toxins |
Release Date: | 2023/07/24 |
Date of first Publication: | 2022/05/11 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |