Reinhold Tacke, H. Hengelsberg, E. Klingner, H. Henke

• The racemic Si-functional acetylsilanes tBu(Me\(_3\)SiCH\(_2\))[ MeC(O)]SiF (1) and tBu(Me\(_3\)SiCH\(_2\))[MeC(O)]SiH (2) and the racemic acetylsilanol tBu(Me\(_3\)SiCH\(_2\))[MeC(O)]SiOH (3) were synthesized from Si(OMe)\(_4\) (4) as substrates for microbial reductions [4 -> tBuSi(OMe)\(_3\) (5) -> tBu(Me\(_3\)SiCH\(_2\))Si(OMe)\(_2\) (6) -> tBu(Me\(_3\)SiCH\(_2\))SiF\(_2\) (7)-> tBu(Me\(_3\)SiCH\(_2\))(CH\(_2\) = C(OMe))SiF (8) -> 1; 8 -> tBu(Me\(_3\)SiCH\(_2\))[CH\(_2\) = C(OMe)]SiH (9) -> 2; 6 -> tBu(Me\(_3\)SiCH\(_2\))[CH\(_2\) =The racemic Si-functional acetylsilanes tBu(Me\(_3\)SiCH\(_2\))[ MeC(O)]SiF (1) and tBu(Me\(_3\)SiCH\(_2\))[MeC(O)]SiH (2) and the racemic acetylsilanol tBu(Me\(_3\)SiCH\(_2\))[MeC(O)]SiOH (3) were synthesized from Si(OMe)\(_4\) (4) as substrates for microbial reductions [4 -> tBuSi(OMe)\(_3\) (5) -> tBu(Me\(_3\)SiCH\(_2\))Si(OMe)\(_2\) (6) -> tBu(Me\(_3\)SiCH\(_2\))SiF\(_2\) (7)-> tBu(Me\(_3\)SiCH\(_2\))(CH\(_2\) = C(OMe))SiF (8) -> 1; 8 -> tBu(Me\(_3\)SiCH\(_2\))[CH\(_2\) = C(OMe)]SiH (9) -> 2; 6 -> tBu(Me\(_3\)SiCH\(_2\))[CH\(_2\) = C(OMe)]SiOMe (10) -> 3]. Compounds 1-3 were found to be reduced by cells of Trigonapsis variabilis (DSM 70714) ( = SiC(O)Me -> = SiCH(OH)Me}. The crystal and molecular structure of 3 was studied by singlecrystal X-ray diffraction. In the crystal, racemic 3 forms infinite chains built up by intermolecular 0-H .. ·O bonds between the hydroxyl and acetyl groups of molecules of the same absolute configuration.…