Respiratory \(\mu\)-Opioid and benzodiazepine interactions in the understrained rat
Please always quote using this URN: urn:nbn:de:bvb:20-opus-62974
- lnteractions of p-opioid receptors with the benzodiazepine system were studied by examining the modulatory effects of flumazenil (a benzodiazepine antagonist) and alprazolam (a benzodiazepine agonist) on the respiratory effects ofthe opioid peptide dermorphin. Dermorphin, 1-30 nmol administered i.c.v., to conscious, unrestrained rats decreased ventilation rate (VR) and minute volume (MV) dose-dependently. The ventilatory depression was antagonized by naloxone and by the benzodiazepine antagonist flumazenil. The benzodiazepine alprazolamlnteractions of p-opioid receptors with the benzodiazepine system were studied by examining the modulatory effects of flumazenil (a benzodiazepine antagonist) and alprazolam (a benzodiazepine agonist) on the respiratory effects ofthe opioid peptide dermorphin. Dermorphin, 1-30 nmol administered i.c.v., to conscious, unrestrained rats decreased ventilation rate (VR) and minute volume (MV) dose-dependently. The ventilatory depression was antagonized by naloxone and by the benzodiazepine antagonist flumazenil. The benzodiazepine alprazolam potentiateri the respiratory inhibition of a small (I nmol) dose of dermorphin but antagonized that of a higher dos:~ (3 nmol). The results suggest that the benzodiazepine/GABA receptor complex modulates respiratory depression induced by centrat p-receptor Stimulation in the rat.…
Author: | P. Paakkari, I. Paakkari, P. Landes, Anna-Leena Sirén, G. Feuerstein |
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URN: | urn:nbn:de:bvb:20-opus-62974 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Neurochirurgische Klinik und Poliklinik |
Language: | English |
Year of Completion: | 1993 |
Source: | In: Neuropharmacology (1993) 32, 323-329. |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
GND Keyword: | Neurobiologie |
Tag: | benzodiazepine antagonist.; dermorphin; flumazenil; opioid receptors; opioid-benzodiazepine interactions; respiration |
Release Date: | 2012/07/26 |
Licence (German): | Deutsches Urheberrecht |