A tolane-modified 5-ethynyluridine as a universal and fluorogenic photochemical DNA crosslinker
Please always quote using this URN: urn:nbn:de:bvb:20-opus-328255
- We report the fluorescent nucleoside ToldU and its application as a photoresponsive crosslinker in three different DNA architectures with enhanced fluorescence emission of the crosslinked products. The fluorogenic ToldU crosslinking reaction enables the assembly of DNA polymers in a hybridization chain reaction for the concentration-dependent detectio of a specific DNA sequence.
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| Author: | Hermann NeitzORCiD, Claudia HöbartnerORCiD |
|---|---|
| URN: | urn:nbn:de:bvb:20-opus-328255 |
| Document Type: | Preprint |
| Faculties: | Fakultät für Chemie und Pharmazie / Institut für Organische Chemie |
| Language: | English |
| Parent Title (English): | Chemical Communications |
| Year of Completion: | 2023 |
| Edition: | submitted version |
| Source: | Chemical Communications (2023) 59:12003-12006. DOI: 10.1039/D3CC03796G |
| DOI: | https://doi.org/10.1039/D3CC03796G |
| Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 54 Chemie / 547 Organische Chemie |
| Tag: | Photoresponsive DNA Crosslinker; Tolane-Modified Fluorescent Nucleosides |
| Release Date: | 2023/10/10 |
| Licence (German): |  Deutsches Urheberrecht |