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Effects of barbiturates on A1 adenosine receptors of rat brain

Please always quote using this URN: urn:nbn:de:bvb:20-opus-70100
  • Barbiturates inhibit binding of radioligands to A 1(Ri) adenosine receptors of rat brain membranes. This inhibition is dose-dependent and stereospecific and occurs in the range of pharmacologically active concentrations. The displacement of radiolabelled A1antagonists by barbiturates is not modified by GTP, indicating that barbiturates might act as antagonists at this receptor. This action of barbiturates does not seem to be related to the binding of barbiturates to plasma membranes, as the latter process has different characteristics.Barbiturates inhibit binding of radioligands to A 1(Ri) adenosine receptors of rat brain membranes. This inhibition is dose-dependent and stereospecific and occurs in the range of pharmacologically active concentrations. The displacement of radiolabelled A1antagonists by barbiturates is not modified by GTP, indicating that barbiturates might act as antagonists at this receptor. This action of barbiturates does not seem to be related to the binding of barbiturates to plasma membranes, as the latter process has different characteristics. Barbiturates also inhibit the binding of radioligands to solubilized A1receptors, and saturation and kinetic experiments suggest that this is due to a competitive antagonism. These results indicate that barbiturates interact with the recognition site of the A1adenosine receptor.show moreshow less

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Metadaten
Author: Martin J. Lohse, Karl-Norbert Klotz, Ulrich Schwabe
URN:urn:nbn:de:bvb:20-opus-70100
Document Type:Book article / Book chapter
Faculties:Medizinische Fakultät / Institut für Pharmakologie und Toxikologie
Language:English
Year of Completion:1985
Source:In: Adenosine: receptors and modulation of cell funtion / V. Stefanovic ... eds. - Oxford [u.a.]: IRL Pr., 1985, S.221-231. - ISBN: 0-947946-49-7
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
GND Keyword:Barbiturat; Adenosinrezeptor; Ratte
Release Date:2014/05/19
Licence (German):License LogoDeutsches Urheberrecht