An experimental protocol for mimicking pathomechanisms of traumatic brain injury in mice
Please always quote using this URN: urn:nbn:de:bvb:20-opus-75368
- Traumatic brain injury (TBI) is a result of an outside force causing immediate mechanical disruption of brain tissue and delayed pathogenic events. In order to examine injury processes associated with TBI, a number of rodent models to induce brain trauma have been described. However, none of these models covers the entire spectrum of events that might occur in TBI. Here we provide a thorough methodological description of a straightforward closed head weight drop mouse model to assess brain injuries close to the clinical conditions of human TBI.Traumatic brain injury (TBI) is a result of an outside force causing immediate mechanical disruption of brain tissue and delayed pathogenic events. In order to examine injury processes associated with TBI, a number of rodent models to induce brain trauma have been described. However, none of these models covers the entire spectrum of events that might occur in TBI. Here we provide a thorough methodological description of a straightforward closed head weight drop mouse model to assess brain injuries close to the clinical conditions of human TBI.…
Author: | Christiane Albert-Weißenberger, Csanád Várrallyay, Furat Raslan, Christoph Kleinschnitz, Anna-Leena Sirén |
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URN: | urn:nbn:de:bvb:20-opus-75368 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Neurologische Klinik und Poliklinik |
Language: | English |
Year of Completion: | 2012 |
Source: | In: Experimental & Translational Stroke Medicine (2012) 4: 1, doi:10.1186/2040-7378-4-1 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
GND Keyword: | Medizin |
Tag: | astrocyte; closed head injury; microglia; neurobehavioural deficits; neurons; traumatic brain injury |
Release Date: | 2013/03/25 |
Collections: | Open-Access-Publikationsfonds / Förderzeitraum 2012 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung |