Karyotype complexity and prognosis in acute myeloid leukemia
Please always quote using this URN: urn:nbn:de:bvb:20-opus-164530
- A complex aberrant karyotype consisting of multiple unrelated cytogenetic abnormalities is associated with poor prognosis in patients with acute myeloid leukemia (AML). The European Leukemia Net classification and the UK Medical Research Council recommendation provide prognostic categories that differ in the definition of unbalanced aberrations as well as the number of single aberrations. The aim of this study on 3526 AML patients was to redefine and validate a cutoff for karyotype complexity in AML with regard to adverse prognosis. Our studyA complex aberrant karyotype consisting of multiple unrelated cytogenetic abnormalities is associated with poor prognosis in patients with acute myeloid leukemia (AML). The European Leukemia Net classification and the UK Medical Research Council recommendation provide prognostic categories that differ in the definition of unbalanced aberrations as well as the number of single aberrations. The aim of this study on 3526 AML patients was to redefine and validate a cutoff for karyotype complexity in AML with regard to adverse prognosis. Our study demonstrated that (1) patients with a pure hyperdiploid karyotype have an adverse risk irrespective of the number of chromosomal gains, (2) patients with translocation t(9;11)(p21∼22;q23) have an intermediate risk independent of the number of additional aberrations, (3) patients with 4 abnormalities have an adverse risk per se and (4) patients with three aberrations in the absence of abnormalities of strong influence (hyperdiploid karyotype, t(9;11)(p21∼22;q23), CBF-AML, unique adverse-risk aberrations) have borderline intermediate/adverse risk with a reduced overall survival compared with patients with a normal karyotype.…
Author: | F. Stölzel, B. Mohr, M. Kramer, U. Oelschlägel, T. Bochtler, W. E. Berdel, M. Kaufmann, C. D. Baldus, K. Schäfer-Eckart, R. Stuhlmann, H. Einsele, S. W. Krause, H. Serve, M. Hänel, R. Herbst, A. Neubauer, K. Sohlbach, J. Mayer, J. M. Middeke, U. Platzbecker, M. Schaich, A. Krämer, C. Röllig, J. Schetelig, M. Bornhäuser, G. Ehninger |
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URN: | urn:nbn:de:bvb:20-opus-164530 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Medizinische Klinik und Poliklinik II |
Language: | English |
Parent Title (English): | Blood Cancer Journal |
Year of Completion: | 2016 |
Volume: | 6 |
Pagenumber: | e386 |
Source: | Blood Cancer Journal (2016) 6, e386 |
DOI: | https://doi.org/10.1038/bcj.2015.114 |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | Cancer genetics; Genetics research |
Release Date: | 2020/01/08 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |