Covalent binding of aflatoxin B\(_1\) to liver DNA in rats pretreated with ethanol
Please always quote using this URN: urn:nbn:de:bvb:20-opus-55237
- Male Fischer F-344 rats were given ethanol in the drinking water and/or by single oral administration. Following this, the animals received p.o. 100 ng/kg of the hepatocarcinogen eHJaflatoxin BI (AFBI)' 24 h later, the level of DNA-bound AFBI was determined in the liver and was found not to be affected by any type of ethanol pretreatment. A cocarcinogenic effect of ethanol in the liver is therefore unlikely to be due to an effect on the metabolic activation and inactivation processes governing the formation of DNA-binding AFBI metabolites.
Author: | M. Marinovich, Werner K. Lutz |
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URN: | urn:nbn:de:bvb:20-opus-55237 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Institut für Pharmakologie und Toxikologie |
Language: | English |
Parent Title (German): | Experientia |
Year of Completion: | 1985 |
Volume: | 41 |
Issue: | 10 |
First Page: | 1338 |
Last Page: | 1340 |
Source: | Experientia (1985) 41, 10, 1338-1340. |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
GND Keyword: | Toxikologie |
Tag: | Carcinogenesis; DNA; aflatoxin; covalent binding; ethanol |
Release Date: | 2011/03/30 |
Licence (German): | Deutsches Urheberrecht |