Comprehensive geriatric assessment and quality of life aspects in patients with recurrent/metastatic head and neck squamous cell carcinoma (HNSCC)
Please always quote using this URN: urn:nbn:de:bvb:20-opus-363096
- To define frailty in older cancer patients, the aim of this study was to assess the geriatric status and quality of life (QoL) aspects in patients suffering from recurrent/metastatic head and neck squamous cell carcinoma (r/m HNSCC) under palliative treatment. A comprehensive geriatric assessment (CGA) was performed on 21 r/m HNSCC patients at two defined assessments, and the QoL aspects and the impact of descriptive data were evaluated. The Kolmogorov–Smirnov test, Spearman’s rho correlation, and two-way mixed ANOVA were used for statisticalTo define frailty in older cancer patients, the aim of this study was to assess the geriatric status and quality of life (QoL) aspects in patients suffering from recurrent/metastatic head and neck squamous cell carcinoma (r/m HNSCC) under palliative treatment. A comprehensive geriatric assessment (CGA) was performed on 21 r/m HNSCC patients at two defined assessments, and the QoL aspects and the impact of descriptive data were evaluated. The Kolmogorov–Smirnov test, Spearman’s rho correlation, and two-way mixed ANOVA were used for statistical analysis. All patients were found to be “frail”. Pain, fatigue, and the burden of illness were the highest-rated symptoms. Oral function and orofacial appearance were highly impaired. A significant impact of descriptive data on the CGA and QoL results was found (all p ≤ 0.05). Thus, the CGA results revealed high frailty, severe comorbidities, and high impairments in QoL aspects. The CGA and QoL results were negatively affected by the primary HNSCC treatment approach, the need for prosthetic treatment, and worse oral functional capacity. Therefore, frailty in r/m HNSCC patients seems to be multidimensional. The evaluation of the CGA and QoL aspects in r/m HNSCC patients can be recommended to detect special needs, organize aftercare, and improve the support for frail and vulnerable cancer patients to create a multidisciplinary treatment approach.…
| Author: | Anna WinterORCiD, Stefan M. SchulzORCiD, Marc Schmitter, Urs Müller-RichterORCiD, Alexander Kübler, Sylvia Kasper, Stefan Hartmann |
|---|---|
| URN: | urn:nbn:de:bvb:20-opus-363096 |
| Document Type: | Journal article |
| Faculties: | Medizinische Fakultät / Klinik und Poliklinik für Mund-, Kiefer- und Plastische Gesichtschirurgie |
| Medizinische Fakultät / Poliklinik für Zahnärztliche Prothetik | |
| Language: | English |
| Parent Title (English): | Journal of Clinical Medicine |
| ISSN: | 2077-0383 |
| Year of Completion: | 2023 |
| Volume: | 12 |
| Issue: | 17 |
| Article Number: | 5738 |
| Source: | Journal of Clinical Medicine (2023) 12:17, 5738. https://doi.org/10.3390/jcm12175738 |
| DOI: | https://doi.org/10.3390/jcm12175738 |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Tag: | frailty; geriatric cancer patient; oral functional capacity; oral health-related quality of life; prosthetic rehabilitation; recurrent/metastatic head and neck squamous cell carcinoma |
| Release Date: | 2024/06/13 |
| Licence (German): |  CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |