Disruption of the CNTF gene results in motor neuron degeneration

Please always quote using this URN: urn:nbn:de:bvb:20-opus-33038
  • CNTF is a cytosolic molecule expressed postnatally in myelinating Schwann cells and in a subpopulation of astrocytes. Although CNTF administration prevents lesion-mediated and genetically determined motor neuron degeneration, its physiological function remained elusive. Here it is reported that abolition of CNTF gene expression by homologous recombination results in a progressive atrophy and loss of motor neurons in adult mice, which is functionally reflected by a small but significant reduction in muscle strength.

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Author: Yasuo Masu, Eckhard Wolf, Bettina Holtmann, Michael Sendtner, Gottfried Brem, Hans Thoenen
Document Type:Journal article
Faculties:Medizinische Fakultät / Institut für Klinische Neurobiologie
Year of Completion:1993
Source:In: Nature (1993) 365, 27-32.
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Release Date:2009/08/25