Mikrobiologische Umwandlung von Silicium-Verbindungen: Enantioselektive Reduktion von Acetessigsäure-(trimethylsilylalkyl)estern und deren Carba-Analoga

Microbiological Transformation of Silicon Compounds: Enantioselective Reduction of Trimethylsilylalkyl Acetoacetates and their Carba-Analogues

Please always quote using this URN: urn:nbn:de:bvb:20-opus-128304
  • The trimethylsilylalkyl acetoacetates 1 b and 2 b as well as their carba analogues 1 a and 2 a have been reduced microbiologically by Kloeckera corticis (ATCC 20109), leading to the corresponding ( + )-3(S)-hydroxybutanoates 3b, 4b, 3a, and 4a. The enantiomeric purity was found to be 80% (3a, 3b, 4b) and 65% (4a), respectively. The reduction of lb and 2b is - to our knowledge - the first example for a controlled microbiological transformation of organosilicon substrates.

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Author: Reinhold Tacke, Haryanto Linoh, Burghard Stumpf, Wolf-Rainer Abraham, Klaus Kieslich, Ludger Ernst
Document Type:Journal article
Faculties:Fakultät für Chemie und Pharmazie / Institut für Anorganische Chemie
Parent Title (German):Zeitschrift für Naturforschung B
Year of Completion:1983
Source:Zeitschrift für Naturforschung B. Band 38, Heft 5, Seiten 616–620
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 54 Chemie / 546 Anorganische Chemie
Tag:enantioselective reduction; microbiological transformation; silicon compounds
Release Date:2016/03/01
Licence (German):License LogoDeutsches Urheberrecht