Sila-Pharmaka, 26. Mitt. [1] Darstellung und Eigenschaften potentiell curarewirksamer Silicium-Verbindungen, III

Sila-Pharmaca, 26th Communication [1] Preparation and Properties of Silicon Compounds with Potential Curare-Like Activity, III

Please always quote using this URN: urn:nbn:de:bvb:20-opus-128402
  • The potentially curare-like silicon compounds 8a- 8f were synthesized and investigated with respect to their structure-activity relationships. The conformations of the compounds in the solid state and in solution were studied by X-ray diffraction analysis (8a- 8e) and IR NMR spectroscopy (8a- 8f), respectively. The muscle relaxing properties of 8a- 8f were investigated on the mouse. The observed structure-activity relationships are not in accordance with the classical "14 Å model" for neuromuscular blocking agents.

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Author: Reinhold Tacke, Haryanto Linoh, Moayad T. Attar-Bashi, William S. Sheldrick, Ludger Ernst, Roland Niedner, Joachim Frohnecke
Document Type:Journal article
Faculties:Fakultät für Chemie und Pharmazie / Institut für Anorganische Chemie
Parent Title (German):Zeitschrift für Naturforschung B
Year of Completion:1982
Source:Zeitschrift für Naturforschung B 37, 1461- 1471 (1982)
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 54 Chemie / 546 Anorganische Chemie
Tag:X-ray; conformational anaylses; curare-lik activity; silicon compounds; structure-activity relationships
Release Date:2016/03/01
Licence (German):License LogoDeutsches Urheberrecht