Myocardial Infarction After High-Dose Catecholamine Application—A Case Report From an Experimental Imaging Study
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-217959
- Although heart failure following myocardial infarction (MI) represents a major health burden, underlying microstructural and functional changes remain incompletely understood. Here, we report on a case of unexpected MI after treatment with the catecholamine isoproterenol in an experimental imaging study in mice using different state-of-the-art imaging modalities. The decline in cardiac function was documented by ultrahigh-frequency echocardiography and speckle-tracking analyses. Myocardial microstructure was studied ex vivo at a spatialAlthough heart failure following myocardial infarction (MI) represents a major health burden, underlying microstructural and functional changes remain incompletely understood. Here, we report on a case of unexpected MI after treatment with the catecholamine isoproterenol in an experimental imaging study in mice using different state-of-the-art imaging modalities. The decline in cardiac function was documented by ultrahigh-frequency echocardiography and speckle-tracking analyses. Myocardial microstructure was studied ex vivo at a spatial resolution of 100 × 100 × 100 μm\(^{3}\) using diffusion tensor magnetic resonance imaging (DT-MRI) and histopathologic analyses. Two weeks after ISO treatment, the animal showed an apical aneurysm accompanied by reduced radial strain in corresponding segments and impaired global systolic function. DT-MRI revealed a loss of contractile fiber tracts together with a disarray of remaining fibers as corresponding microstructural correlates. This preclinical case report provides valuable insights into pathophysiology and morphologic–functional relations of heart failure following MI using emerging imaging technologies.…
Autor(en): | Niklas Beyhoff, David Lohr, Arne Thiele, Anna Foryst-Ludwig, Robert Klopfleisch, Laura M. Schreiber, Ulrich Kintscher |
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URN: | urn:nbn:de:bvb:20-opus-217959 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Deutsches Zentrum für Herzinsuffizienz (DZHI) |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Frontiers in Cardiovascular Medicine |
Erscheinungsjahr: | 2020 |
Band / Jahrgang: | 7 |
Aufsatznummer: | 580296 |
Originalveröffentlichung / Quelle: | Frontiers in Cardiovascular Medicine 2020, 7:580296. DOI: 10.3389/fcvm.2020.580296 |
DOI: | https://doi.org/10.3389/fcvm.2020.580296 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | case report; catecholamines; diffusion tensor imaging; echocardiography; heart failure; magnetic resonance imaging; myocardial infarction; speckle tracking |
Datum der Freischaltung: | 31.01.2022 |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |