The revival of surgery in Crohn's disease — early intestinal resection as a reasonable alternative in localized ileitis
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- Crohn's disease (CD) represents a heterogeneous and complex disease with no curative therapeutic option available to date. Current therapy is mainly antibody-based focusing on the immune system while other treatment alternatives such as surgery are considered to be “last options”. However, medical therapy for CD results in mild to severe side effects in a relevant amount of patients and some patients do not respond to the medication. Following that, quality of life is often significantly reduced in this patient cohort, thus, therapeuticCrohn's disease (CD) represents a heterogeneous and complex disease with no curative therapeutic option available to date. Current therapy is mainly antibody-based focusing on the immune system while other treatment alternatives such as surgery are considered to be “last options”. However, medical therapy for CD results in mild to severe side effects in a relevant amount of patients and some patients do not respond to the medication. Following that, quality of life is often significantly reduced in this patient cohort, thus, therapeutic alternatives are urgently needed. Updated evidence has revealed that surgery such as ileocecal resection (ICR) might be a potential therapeutic option in case of localized terminal ileitis since resection at early time points improves quality of life and significantly reduces the postoperative need for immunosuppressive medication with low rates of morbidity. In addition, new surgical approaches such as Kono-S anastomosis or inclusion of the mesentery result in significantly reduced rates of disease recurrence and reoperation. Based on the new evidence, the goal of this review is to provide an update on the role of surgery as a reasonable alternative to medical therapy in the interdisciplinary treatment of patients with CD.…
Autor(en): | Matthias Kelm, Christoph-Thomas Germer, Nicolas Schlegel, Sven Flemming |
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URN: | urn:nbn:de:bvb:20-opus-246296 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Klinik und Poliklinik für Allgemein-, Viszeral-, Gefäß- und Kinderchirurgie (Chirurgische Klinik I) |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Biomedicines |
ISSN: | 2227-9059 |
Erscheinungsjahr: | 2021 |
Band / Jahrgang: | 9 |
Heft / Ausgabe: | 10 |
Aufsatznummer: | 1317 |
Originalveröffentlichung / Quelle: | Biomedicines (2021) 9:10, 1317. https://doi.org/10.3390/biomedicines9101317 |
DOI: | https://doi.org/10.3390/biomedicines9101317 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | Crohn's disease; inflammatory bowel disease; surgery; surgical outcome; terminal ileitis |
Datum der Freischaltung: | 17.11.2022 |
Datum der Erstveröffentlichung: | 26.09.2021 |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |