Genotoxic activity of the new pharmaceutical FS-1 in Salmonella/microsome test and mouse lymphoma L5178Y cells
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-143769
- Purpose: The purpose of this study was to determine possible genotoxic effects of a new very promising antibacterial/ antiviral drug FS-1. Methods: The drug was tested in TA98, TA100, TA102, TA 1535 and TA1537 strains of Salmonella (Ames test) with and without metabolic activation, and also in mouse lymphoma L5178Y cells by means of micronucleus and comet assays. In microbes the drug was tested at concentrations up to 500 \(\mu\)g/plate and in mouse lymphoma cells up to 2,000 \(\mu\)g/ml. Results: In both test-systems in allPurpose: The purpose of this study was to determine possible genotoxic effects of a new very promising antibacterial/ antiviral drug FS-1. Methods: The drug was tested in TA98, TA100, TA102, TA 1535 and TA1537 strains of Salmonella (Ames test) with and without metabolic activation, and also in mouse lymphoma L5178Y cells by means of micronucleus and comet assays. In microbes the drug was tested at concentrations up to 500 \(\mu\)g/plate and in mouse lymphoma cells up to 2,000 \(\mu\)g/ml. Results: In both test-systems in all experiments completely negative results were obtained although FS-1 was tested at maximum tolerated doses. Conclusions: The drug is not genotoxic. This is advantageous because many antibacterial/antiviral drugs possess such activity.…
Autor(en): | Alexander Ilin, Murat Kulmanov, Armen Nersesyan, Helga Stopper |
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URN: | urn:nbn:de:bvb:20-opus-143769 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Institut für Pharmakologie und Toxikologie |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Journal of BUON |
Erscheinungsjahr: | 2015 |
Band / Jahrgang: | 20 |
Heft / Ausgabe: | 2 |
Seitenangabe: | 595-601 |
Originalveröffentlichung / Quelle: | Journal of BUON 2015; 20(2): 595-601 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | Salmonella/microsome assay; antibacterial/antiviral drug; comet assay; micronucleus test; mouse lymphoma L5178Y; mutagenicity |
Datum der Freischaltung: | 01.06.2018 |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |