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Efforts of the human immune system to maintain the peripheral CD8+ T cell compartment after childhood thymectomy
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-146497
- Background Homeostatic mechanisms to maintain the T cell compartment diversity indicate an ongoing process of thymic activity and peripheral T cell renewal during human life. These processes are expected to be accelerated after childhood thymectomy and by the influence of cytomegalovirus (CMV) inducing a prematurely aged immune system. The study aimed to investigate proportional changes and replicative history of CD8+ T cells, of recent thymic emigrants (RTEs) and CD103+ T cells (mostly gut-experienced) and the role of Interleukin-(IL)-7Background Homeostatic mechanisms to maintain the T cell compartment diversity indicate an ongoing process of thymic activity and peripheral T cell renewal during human life. These processes are expected to be accelerated after childhood thymectomy and by the influence of cytomegalovirus (CMV) inducing a prematurely aged immune system. The study aimed to investigate proportional changes and replicative history of CD8+ T cells, of recent thymic emigrants (RTEs) and CD103+ T cells (mostly gut-experienced) and the role of Interleukin-(IL)-7 and IL-7 receptor (CD127)-expressing T cells in thymectomized patients compared to young and old healthy controls. Results Decreased proportions of naive and CD31 + CD8+ T cells were demonstrated after thymectomy, with higher proliferative activity of CD127-expressing T cells and significantly shorter relative telomere lengths (RTLs) and lower T cell receptor excision circles (TRECs). Increased circulating CD103+ T cells and a skewed T cell receptor (TCR) repertoire were found after thymectomy similar to elderly persons. Naive T cells were influenced by age at thymectomy and further decreased by CMV. Conclusions After childhood thymectomy, the immune system demonstrated constant efforts of the peripheral CD8+ T cell compartment to maintain homeostasis. Supposedly it tries to fill the void of RTEs by peripheral T cell proliferation, by at least partly IL-7-mediated mechanisms and by proportional increase of circulating CD103+ T cells, reminiscent of immune aging in elderly. Although other findings were less significant compared to healthy elderly, early thymectomy demonstrated immunological alterations of CD8+ T cells which mimic features of premature immunosenescence in humans.…
Autor(en): | Manuela Zlamy, Giovanni Almanzar, Walther Parson, Christian Schmidt, Johannes Leierer, Birgit Weinberger, Verena Jeller, Karin Unsinn, Matthias Eyrich, Reinhard Würzner, Martina Prelog |
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URN: | urn:nbn:de:bvb:20-opus-146497 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Kinderklinik und Poliklinik |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Immunity & Ageing |
Erscheinungsjahr: | 2016 |
Band / Jahrgang: | 13 |
Heft / Ausgabe: | 3 |
Originalveröffentlichung / Quelle: | Immunity & Ageing (2016) 13:3 DOI 10.1186/s12979-016-0058-z |
DOI: | https://doi.org/10.1186/s12979-016-0058-z |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | CD8; CMV; TCR diversity; TRECs; naive T cells; telomeres; thymectomy |
Datum der Freischaltung: | 04.04.2017 |
Sammlungen: | Open-Access-Publikationsfonds / Förderzeitraum 2016 |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung |