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Reducing central serotonin in adulthood promotes hippocampal neurogenesis
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-168004
- Chronic administration of selective serotonin reuptake inhibitors (SSRIs), which up-regulates central serotonin (5-HT) system function, enhances adult hippocampal neurogenesis. However, the relationship between central 5-HT system and adult neurogenesis has not fully been understood. Here, we report that lowering 5-HT level in adulthood is also able to enhance adult hippocampal neurogenesis. We used tamoxifen (TM)-induced Cre in Pet1-CreER\(^{T2}\) mice to either deplete central serotonergic (5-HTergic) neurons or inactivate 5-HT synthesis inChronic administration of selective serotonin reuptake inhibitors (SSRIs), which up-regulates central serotonin (5-HT) system function, enhances adult hippocampal neurogenesis. However, the relationship between central 5-HT system and adult neurogenesis has not fully been understood. Here, we report that lowering 5-HT level in adulthood is also able to enhance adult hippocampal neurogenesis. We used tamoxifen (TM)-induced Cre in Pet1-CreER\(^{T2}\) mice to either deplete central serotonergic (5-HTergic) neurons or inactivate 5-HT synthesis in adulthood and explore the role of central 5-HT in adult hippocampal neurogenesis. A dramatic increase in hippocampal neurogenesis is present in these two central 5-HT-deficient mice and it is largely prevented by administration of agonist for 5-HTR2c receptor. In addition, the survival of new-born neurons in the hippocampus is enhanced. Furthermore, the adult 5-HT-deficient mice showed reduced depression-like behaviors but enhanced contextual fear memory. These findings demonstrate that lowering central 5-HT function in adulthood can also enhance adult hippocampal neurogenesis, thus revealing a new aspect of central 5-HT in regulating adult neurogenesis.…
Autor(en): | Ning-Ning Song, Yun-Fang Jia, Lei Zhang, Qiong Zhang, Ying Huang, Xiao-Zhen Liu, Ling Hu, Wei Lan, Ling Chen, Klaus-Peter Lesch, Xiaoyan Chen, Lin Xu, Yu-Qiang Ding |
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URN: | urn:nbn:de:bvb:20-opus-168004 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Lehrstuhl für Molekulare Psychiatrie |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Deutsch): | Scientific Reports |
Erscheinungsjahr: | 2016 |
Band / Jahrgang: | 6 |
Heft / Ausgabe: | 20338 |
Originalveröffentlichung / Quelle: | Scientific Reports 6:20338 (2016). DOI: 10.1038/srep20338 |
DOI: | https://doi.org/10.1038/srep20338 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | SSRI; adulthood; hippocampal neurogenesis; serotonin |
Datum der Freischaltung: | 29.08.2019 |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |