An innovative arteriovenous (AV) loop breast cancer model tailored for cancer research
Zitieren Sie bitte immer diese URN: urn:nbn:de:bvb:20-opus-278919
- Animal models are important tools to investigate the pathogenesis and develop treatment strategies for breast cancer in humans. In this study, we developed a new three-dimensional in vivo arteriovenous loop model of human breast cancer with the aid of biodegradable materials, including fibrin, alginate, and polycaprolactone. We examined the in vivo effects of various matrices on the growth of breast cancer cells by imaging and immunohistochemistry evaluation. Our findings clearly demonstrate that vascularized breast cancer microtissues could beAnimal models are important tools to investigate the pathogenesis and develop treatment strategies for breast cancer in humans. In this study, we developed a new three-dimensional in vivo arteriovenous loop model of human breast cancer with the aid of biodegradable materials, including fibrin, alginate, and polycaprolactone. We examined the in vivo effects of various matrices on the growth of breast cancer cells by imaging and immunohistochemistry evaluation. Our findings clearly demonstrate that vascularized breast cancer microtissues could be engineered and recapitulate the in vivo situation and tumor-stromal interaction within an isolated environment in an in vivo organism. Alginate–fibrin hybrid matrices were considered as a highly powerful material for breast tumor engineering based on its stability and biocompatibility. We propose that the novel tumor model may not only serve as an invaluable platform for analyzing and understanding the molecular mechanisms and pattern of oncologic diseases, but also be tailored for individual therapy via transplantation of breast cancer patient-derived tumors.…
Autor(en): | Ran An, Pamela L. Strissel, Majida Al-Abboodi, Jan W. Robering, Reakasame Supachai, Markus Eckstein, Ajay Peddi, Theresa Hauck, Tobias Bäuerle, Aldo R. Boccaccini, Almoatazbellah Youssef, Jiaming Sun, Reiner Strick, Raymund E. Horch, Anja M. Boos, Annika Kengelbach-Weigand |
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URN: | urn:nbn:de:bvb:20-opus-278919 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Pathologisches Institut |
Medizinische Fakultät / Abteilung für Funktionswerkstoffe der Medizin und der Zahnheilkunde | |
Sprache der Veröffentlichung: | Englisch |
Titel des übergeordneten Werkes / der Zeitschrift (Englisch): | Bioengineering |
ISSN: | 2306-5354 |
Erscheinungsjahr: | 2022 |
Band / Jahrgang: | 9 |
Heft / Ausgabe: | 7 |
Aufsatznummer: | 280 |
Originalveröffentlichung / Quelle: | Bioengineering (2022) 9:7, 280. https://doi.org/10.3390/bioengineering9070280 |
DOI: | https://doi.org/10.3390/bioengineering9070280 |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Freie Schlagwort(e): | animal model; arteriovenous loop; breast cancer |
Datum der Freischaltung: | 30.05.2023 |
Datum der Erstveröffentlichung: | 27.06.2022 |
Lizenz (Deutsch): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |