Filtern
Volltext vorhanden
- ja (1) (entfernen)
Gehört zur Bibliographie
- ja (1)
Erscheinungsjahr
- 1979 (1)
Dokumenttyp
Sprache
- Deutsch (1) (entfernen)
Schlagworte
- Aflatoxin (1) (entfernen)
Institut
The determination of a covalent binding of radioactive chemieals to DNA in intact mammalian organisms is proposedas a short-term test for carcinogenicity. The effectiveness of covalent binding to rat liver DNA correlates well with the hepatocarcinogenicity known from long-term bioassays. The binding indices range over more than five orders of rriagnitude between the strongest hepatocarcinogen aflatoxin B 1 and the limit of detection of a binding with 100 f-LCi 14C-labelled chemical. The order of magnitude of binding is therefore a surprisingly good quantitative measure for carcinogenicity. The pattern of DNA binding sites is important especially for small alkylating agents where the determination of total binding might indicate a higher carcinogenic potency than is actually observed.