Bacterial coinfection restrains antiviral CD8 T-cell response via LPS-induced inhibitory NK cells
Please always quote using this URN: urn:nbn:de:bvb:20-opus-240075
- Infection of specific pathogen-free mice with lymphocytic choriomeningitis virus (LCMV) is a widely used model to study antiviral T-cell immunity. Infections in the real world, however, are often accompanied by coinfections with unrelated pathogens. Here we show that in mice, systemic coinfection with E. coli suppresses the LCMV-specific cytotoxic T-lymphocyte (CTL) response and virus elimination in a NK cell- and TLR2/4-dependent manner. Soluble TLR4 ligand LPS also induces NK cell-mediated negative CTL regulation during LCMV infection. NKInfection of specific pathogen-free mice with lymphocytic choriomeningitis virus (LCMV) is a widely used model to study antiviral T-cell immunity. Infections in the real world, however, are often accompanied by coinfections with unrelated pathogens. Here we show that in mice, systemic coinfection with E. coli suppresses the LCMV-specific cytotoxic T-lymphocyte (CTL) response and virus elimination in a NK cell- and TLR2/4-dependent manner. Soluble TLR4 ligand LPS also induces NK cell-mediated negative CTL regulation during LCMV infection. NK cells in LPS-treated mice suppress clonal expansion of LCMV-specific CTLs by a NKG2D- or NCR1-independent but perforin-dependent mechanism. These results suggest a TLR4-mediated immunoregulatory role of NK cells during viral-bacterial coinfections.…
Author: | Tobias Straub, Marina A. Freudenberg, Ulrike Schleicher, Christian Bogdan, Georg Gasteiger, Hanspeter Pircher |
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URN: | urn:nbn:de:bvb:20-opus-240075 |
Document Type: | Journal article |
Faculties: | Medizinische Fakultät / Institut für Systemimmunologie |
Language: | English |
Parent Title (English): | Nature Communications |
Year of Completion: | 2018 |
Volume: | 9 |
Article Number: | 4117 |
Source: | Nature Communications (2018) 9:4117. https://doi.org/10.1038/s41467-018-06609-z |
DOI: | https://doi.org/10.1038/s41467-018-06609-z |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Tag: | viral infection Bacterial infection; infection; lymphocyte activation |
Release Date: | 2024/07/18 |
Licence (German): | CC BY: Creative-Commons-Lizenz: Namensnennung 4.0 International |