An analytical model which determines the apparent T1 for Modified Look-Locker Inversion Recovery – Analysis of the longitudinal relaxation under the influence of discontinuous balanced (classical MOLLI) and spoiled gradient echo readouts
Please always quote using this URN: urn:nbn:de:bvb:20-opus-325498
- Quantitative nuclear magnetic resonance imaging (MRI) shifts more and more into the focus of clinical research. Especially determination of relaxation times without/and with contrast agents becomes the foundation of tissue characterization, e.g. in cardiac MRI for myocardial fibrosis. Techniques which assess longitudinal relaxation times rely on repetitive application of readout modules, which are interrupted by free relaxation periods, e.g. the Modified Look-Locker Inversion Recovery = MOLLI sequence. These discontinuous sequences reveal anQuantitative nuclear magnetic resonance imaging (MRI) shifts more and more into the focus of clinical research. Especially determination of relaxation times without/and with contrast agents becomes the foundation of tissue characterization, e.g. in cardiac MRI for myocardial fibrosis. Techniques which assess longitudinal relaxation times rely on repetitive application of readout modules, which are interrupted by free relaxation periods, e.g. the Modified Look-Locker Inversion Recovery = MOLLI sequence. These discontinuous sequences reveal an apparent relaxation time, and, by techniques extrapolated from continuous readout sequences, a putative real T1 is determined. What is missing is a rigorous analysis of the dependence of the apparent relaxation time on its real partner, readout sequence parameters and biological parameters as heart rate. This is provided in this paper for the discontinuous balanced steady state free precession (bSSFP) and spoiled gradient echo readouts. It turns out that the apparent longitudinal relaxation rate is the time average of the relaxation rates during the readout module, and free relaxation period. Knowing the heart rate our results vice versa allow to determine the real T1 from its measured apparent partner.…
Title Additional (German): | Ein analytisches Modell, das die apparente T1 Zeit für Modfied Look-Locker Inversion Recovery bestimmt-Analyse der longitudinalen Relaxation unter dem Einfluss diskontinuierlicher balanced (klassische MOLLI) und spoiled gradient echo readouts |
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Author: | Thomas Kampf, Theresa Reiter, Wolfgang Rudolf Bauer |
URN: | urn:nbn:de:bvb:20-opus-325498 |
Document Type: | Journal article |
Faculties: | Fakultät für Physik und Astronomie / Physikalisches Institut |
Medizinische Fakultät / Medizinische Klinik und Poliklinik II | |
Medizinische Fakultät / Deutsches Zentrum für Herzinsuffizienz (DZHI) | |
Language: | English |
Parent Title (German): | Zeitschrift für Medizinische Physik |
Year of Completion: | 2018 |
Volume: | 28 |
Pagenumber: | 150-157 |
Source: | Zeitschrift für Medizinische Physik (2018) 28:150-157. https://doi.org/10.1016/j.zemedi.2017.07.004 |
DOI: | https://doi.org/10.1016/j.zemedi.2017.07.004 |
Dewey Decimal Classification: | 5 Naturwissenschaften und Mathematik / 53 Physik / 530 Physik |
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit | |
Tag: | Lock Locker; MOLLI; T1; T2; balanced steady state free precession; longitudinal relaxation; spoiled gradient echo |
Release Date: | 2024/08/22 |
Licence (German): | ![]() |