Assessment of damage from implantation of microdialysis probes in the rat hippocampus with silver degeneration staining
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- We used a sensitive silver degeneration staining method to study the effects of insertion of microdialysis probes in rat dorsal hippocampus and neocortex. Nine animals were sacrificed 24 h, 3 days or 7 days after implantation of dialysis tubing. Although mild neuronal cell death and small petechial hemorrhages were seen in elose proximity to the implantation site, the striking finding was the presence of degenerating axons both adjacent to the implantation site and in remote sites such as the corpus callosum and contralateral hippocampus. TheWe used a sensitive silver degeneration staining method to study the effects of insertion of microdialysis probes in rat dorsal hippocampus and neocortex. Nine animals were sacrificed 24 h, 3 days or 7 days after implantation of dialysis tubing. Although mild neuronal cell death and small petechial hemorrhages were seen in elose proximity to the implantation site, the striking finding was the presence of degenerating axons both adjacent to the implantation site and in remote sites such as the corpus callosum and contralateral hippocampus. The observed changes could alter brain function near or remote from the implantation site and should be considered in analysis of dialysis experiments.…
Autor(en): | A. Shuaib, K. Xu, B. Crain, Anna-Leena Sirén, Giora Feuerstein, J. Hallenbeck, JN Davis |
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URN: | urn:nbn:de:bvb:20-opus-47433 |
Dokumentart: | Artikel / Aufsatz in einer Zeitschrift |
Institute der Universität: | Medizinische Fakultät / Neurochirurgische Klinik und Poliklinik |
Sprache der Veröffentlichung: | Englisch |
Erscheinungsjahr: | 1990 |
Originalveröffentlichung / Quelle: | In: Neuroscience Letters (1990) 112, 149-154. |
Allgemeine fachliche Zuordnung (DDC-Klassifikation): | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Normierte Schlagworte (GND): | Neurophysiologie; Neurobiologie |
Freie Schlagwort(e): | Axonal degeneration; In-vivo dia lysis; Rat hippocampus; Silver degeneration staining |
Datum der Freischaltung: | 12.01.2011 |
Lizenz (Deutsch): | Deutsches Urheberrecht |